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This study aimed to investigate the relationship between objectively assessed tobacco smoke exposure and specific IgE profiles for a broad spectrum of allergens in a population setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 5\u201318 years (<jats:italic>N<\/jats:italic> = 1315) were assessed using serum cotinine measurement and microarray\u2010based multiplexed detection of specific IgE against 40 allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum cotinine levels were positively associated with sensitization to foods (adjusted odds ratio [AOR] = 4.95; 95% CI: 1.59\u201315.34), cockroaches (AOR = 3.77; 95% CI: 1.49\u20139.51), and pollen (AOR = 2.84; 95% CI: 1.20\u20136.73) while the association was borderline significant for animals (AOR = 2.53; 95% CI: 0.92\u20136.93). No associations were found for sensitization against mites, mold, and latex. When considering the degree of allergic sensitization, serum cotinine levels were positively correlated to the number of sensitization to cockroaches (<jats:italic>P<\/jats:italic> = 0.004), pollen (<jats:italic>P<\/jats:italic> = 0.006), and foods (<jats:italic>P<\/jats:italic> &lt; 0.001), with statistically significant positive dose\u2013response relationships (all <jats:italic>P<\/jats:italic> &lt; 0.01). Similar results were observed when summing up specific IgE concentrations for the aforementioned allergen categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between tobacco smoke exposure and IgE sensitization to environmental allergens varies for different allergens among children. This study demonstrates that elevated serum cotinine levels are significantly associated with IgE sensitization to cockroaches, grass pollen, and certain foods, with potential dose\u2010dependent relationships.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12775","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:54:46Z","timestamp":1443488086000},"page":"90-98","source":"Crossref","is-referenced-by-count":22,"title":["Tobacco smoke exposure and multiplexed immunoglobulin E sensitization in children: a population\u2010based study"],"prefix":"10.1111","volume":"71","author":[{"given":"T.\u2010C.","family":"Yao","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Community Medicine Research Center Chang Gung Memorial Hospital at Keelung Keelung 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