{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:53:41Z","timestamp":1792666421406,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004726","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>\n \n Studies examining the long\u2010term effect of oral immunotherapy in food\u2010allergic patients are limited. We investigated cow's milk\u2010allergic patients, >6\u00a0months after the completion of oral immunotherapy (\n n<\/jats:italic>\n \u00a0=\u00a0197). Questionnaires, skin prick tests, and basophil activation assays were performed. Of the 195 patients contacted, 180 (92.3%) were consuming milk protein regularly. Half experienced adverse reactions, mostly mild. Thirteen patients (6.7%) required injectable epinephrine. Higher reaction rate after immunotherapy was associated with more anaphylactic episodes before treatment and a lower starting dose (\n OR<\/jats:styled-content>\n \u00a0=\u00a02.1,\n P<\/jats:italic>\n \u00a0=\u00a00.035 and\n OR<\/jats:styled-content>\n \u00a0=\u00a02.3,\n P<\/jats:italic>\n \u00a0=\u00a00.035, respectively). Reaction rate in patients who were 6\u201315\u00a0months, 15\u201330\u00a0months, or >30\u00a0months post\u2010treatment decreased from 0.28\/month to 0.21\/month to 0.15\/month, respectively (\n P<\/jats:italic>\n \u00a0<\u00a00.01). Milk\u2010induced %\n CD<\/jats:styled-content>\n 63 and %\n CD<\/jats:styled-content>\n 203c expression was significantly lower in patients >24\u00a0months\n vs<\/jats:italic>\n in patients <24\u00a0months post\u2010treatment (\n P<\/jats:italic>\n \u00a0=\u00a00.038 and\n P<\/jats:italic>\n \u00a0=\u00a00.047, respectively). In conclusion, many patients experience mild adverse reactions after completing oral immunotherapy and some require injectable epinephrine. Progressive desensitization, both clinically and in basophil reactivity, occurs over time.\n <\/jats:p>","DOI":"10.1111\/all.12794","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T05:07:54Z","timestamp":1445317674000},"page":"275-278","source":"Crossref","is-referenced-by-count":45,"title":["Clinical and laboratory 2\u2010year outcome of oral immunotherapy in patients with cow's milk allergy"],"prefix":"10.1111","volume":"71","author":[{"given":"A.","family":"Elizur","sequence":"first","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"},{"name":"Department of Pediatrics Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Y.","family":"Appel","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yichie","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nachshon","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Katz","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Institute Assaf\u2010Harofeh Medical Center Zerifin Israel"},{"name":"Department of Pediatrics Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0539"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.622"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.021"},{"key":"e_1_2_9_5_1","first-page":"29","article-title":"Lessons from cases of mortality due to food allergy in Israel: cow's milk protein should be considered a potentially fatal allergen","volume":"14","author":"Levy MB","year":"2012","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12398"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12437"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200435"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.10.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03749.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.10.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00670.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-OA-0107"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00542.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.12.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.042"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.039"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1037"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:02:19Z","timestamp":1696471339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/all.12794"],"URL":"https:\/\/doi.org\/10.1111\/all.12794","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]}}}