{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:10:11Z","timestamp":1758636611010},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3\u2010dioxygenase (<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects (<jats:italic>n<\/jats:italic> = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell\u2010mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell\u2010mediated diseases.<\/jats:p>","DOI":"10.1111\/all.12802","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T12:25:37Z","timestamp":1446467137000},"page":"416-420","source":"Crossref","is-referenced-by-count":4,"title":["Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms"],"prefix":"10.1111","volume":"71","author":[{"given":"S.","family":"Georgin\u2010Lavialle","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne H\u00f4pital Tenon Assistance Publique\u2010H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie\u2010Paris 6 Paris France"},{"name":"Centre de R\u00e9f\u00e9rence des Mastocytoses Sorbonne, Paris Cit\u00e9 H\u00f4pital Necker Enfants malades Institut Imagine Universit\u00e9 Paris Descartes Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010M.","family":"Launay","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire H\u00f4pital Lariboisi\u00e8re Assistance Publique\u2010H\u00f4pitaux de Paris INSERM U942 RTRS Sant\u00e9 Mentale Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1163 and CNRS ERL 8254 and Laboratory of Physiopathology and Treatment of Hematological Disorders H\u00f4pital Necker\u2010Enfants malades Institut Imagine Paris Cedex 15 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Souci\u00e9","sequence":"additional","affiliation":[{"name":"INSERM UMR 891 Centre de Recherche en Canc\u00e9rologie de Marseille Laboratoire d'H\u00e9matopo\u00ef\u00e8se Mol\u00e9culaire et Fonctionnelle Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Soria","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Mastocytoses Sorbonne, Paris Cit\u00e9 H\u00f4pital Necker Enfants malades Institut Imagine Universit\u00e9 Paris Descartes Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Damaj","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Mastocytoses Sorbonne, Paris Cit\u00e9 H\u00f4pital Necker Enfants malades Institut Imagine Universit\u00e9 Paris Descartes Paris France"},{"name":"H\u00e9matologie Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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