{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:59Z","timestamp":1787504459641,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370129"],"award-info":[{"award-number":["81370129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n House dust mites are the most prevalent allergen causing sensitizations in patients with rhinitis and asthma in China. We aimed to investigate the changes in both upper and lower airway inflammation and responsiveness following\n Dermatophagoides pteronyssinus<\/jats:italic>\n (\n Der\u2010p<\/jats:italic>\n ) nasal provocation test (\n NPT<\/jats:styled-content>\n ) in rhinitis patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Study subjects included 15 nonasthmatic\n Der\u2010p<\/jats:italic>\n \u2010sensitized rhinitis (\n AR<\/jats:styled-content>\n ) patients with airway hyper\u2010responsiveness (\n AHR<\/jats:styled-content>\n ) (\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n +), 15\n AR<\/jats:styled-content>\n patients without\n AHR<\/jats:styled-content>\n (\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n \u2010), 15 healthy controls (\n HC<\/jats:styled-content>\n s) with\n Der\u2010p<\/jats:italic>\n sensitization (\n HC<\/jats:styled-content>\n +\n DP<\/jats:styled-content>\n +), and 15\n HC<\/jats:styled-content>\n without\n Der\u2010p<\/jats:italic>\n sensitization (\n HC<\/jats:styled-content>\n +\n DP<\/jats:styled-content>\n \u2010). All subjects underwent\n Der\u2010p<\/jats:italic>\n NPT<\/jats:styled-content>\n . Visual analogue scale (\n VAS<\/jats:styled-content>\n ) scores of nasal symptoms, nasal lavage and nasal airway resistance (\n NAR<\/jats:styled-content>\n ) measurement, sputum induction, and forced expiratory volume in 1 second (\n FEV<\/jats:styled-content>\n 1<\/jats:sub>\n ) were performed. Airway responsiveness to histamine bronchoprovocation (\n PD<\/jats:styled-content>\n 20<\/jats:sub>\n \u2010\n FEV<\/jats:styled-content>\n 1<\/jats:sub>\n ) and exhaled nitric oxide (Fe\n NO<\/jats:styled-content>\n ) was determined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n NAR<\/jats:styled-content>\n increased significantly in all subjects with the greatest effect seen in\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n + individuals.\n VAS<\/jats:styled-content>\n increased in all subjects at 30 min and returned to baseline at 6 h, with significantly higher levels in\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n + and\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n \u2010 subjects (\n P<\/jats:italic>\n < 0.05). Eosinophils in nasal lavage fluid and sputum increased significantly after\n NPT<\/jats:styled-content>\n in\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n + and\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n \u2010 subjects (\n P<\/jats:italic>\n < 0.001).\n FEV<\/jats:styled-content>\n 1<\/jats:sub>\n % and\n PD<\/jats:styled-content>\n 20<\/jats:sub>\n \u2010\n FEV<\/jats:styled-content>\n 1<\/jats:sub>\n decreased and Fe\n NO<\/jats:styled-content>\n increased significantly after\n NPT<\/jats:styled-content>\n only in\n AR<\/jats:styled-content>\n +\n AHR<\/jats:styled-content>\n + subjects (\n P<\/jats:italic>\n < 0.05). Nasal lavage eosinophil count was positively correlated with sputum eosinophil count and the level of Fe\n NO<\/jats:styled-content>\n and negatively correlated with\n FEV<\/jats:styled-content>\n 1<\/jats:sub>\n and\n PD<\/jats:styled-content>\n 20<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n House dust mite nasal provocation test induces and aggravates both upper and lower airway inflammation and hyper\u2010responsiveness in patients with persistent allergic rhinitis without asthmatic symptoms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.12808","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T11:21:09Z","timestamp":1448277669000},"page":"378-386","source":"Crossref","is-referenced-by-count":23,"title":["Aggravation of airway inflammation and hyper\u2010responsiveness following nasal challenge with\n Dermatophagoides pteronyssinus<\/i>\n in perennial allergic rhinitis without symptoms of asthma"],"prefix":"10.1111","volume":"71","author":[{"given":"W.","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Department of Allergy and Clinical Immunology The First Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Xian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Department of Allergy and Clinical Immunology The First Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Department of Allergy and Clinical Immunology The First Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Department of Allergy and Clinical Immunology The First Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Department of Allergy and Clinical Immunology The First Affiliated Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology Guangzhou Medical University Guangzhou 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