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Tolerance to aspirin was assessed and challenge was performed with ibuprofen in all cases, and additionally with the culprit drug (if different) in those patients that tolerated ibuprofen. Serum tryptase levels and tryptase immunohistochemical staining in skin biopsies were also assessed in some patients with a positive <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content> to ibuprofen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 245 patients with a confirmed history of <jats:styled-content style=\"fixed-case\">HDR<\/jats:styled-content>s to <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>s, 17% were classified as selective immediate hypersensitivity reactors by both clinical history and challenge. A selective response to naproxen and dexketoprofen with tolerance to ibuprofen was found in 16 of 20 cases. Significant differences in serum tryptase levels were observed between 2 and 24 h in the 11 cases that were studied further.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the group of patients with <jats:styled-content style=\"fixed-case\">HDR<\/jats:styled-content>s to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>s can induce immediate <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>s. Within this group, selective responses to a single drug or responders to several <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>s may exist, suggesting potential immunological cross\u2010reactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12855","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T17:50:29Z","timestamp":1454521829000},"page":"1048-1056","source":"Crossref","is-referenced-by-count":21,"title":["Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives"],"prefix":"10.1111","volume":"71","author":[{"given":"N.","family":"Blanca\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Allergy Service Infanta Leonor University Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"P\u00e9rez\u2010Alzate","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor University Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Andreu","sequence":"additional","affiliation":[{"name":"Chemical Technology Institute UPV\u2010CSIC Polytechnic University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Do\u00f1a","sequence":"additional","affiliation":[{"name":"Allergy Unit Malaga Regional University Hospital\u2010IBIMA, UMA Malaga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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