{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:41:03Z","timestamp":1789890063650,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL84401"],"award-info":[{"award-number":["R01 HL84401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA176726"],"award-info":[{"award-number":["UM1 CA176726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sparse data are available on the relationship between prenatal exposures and asthma during later childhood. In a longitudinal study of adolescents and their mothers, we examined the association of (i) maternal prepregnancy body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and (ii) gestational weight gain (<jats:styled-content style=\"fixed-case\">GWG<\/jats:styled-content>), with incidence of allergic and nonallergic asthma in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analyses were conducted using data from 12 963 children aged 9\u201314 years at enrolment in the Growing Up Today Study, and their mothers, who are participants in the Nurses\u2019 Health Study <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Physician\u2010diagnosed asthma and allergies were assessed by questionnaires sent regularly to participants and their mothers. Logistic regression was used to evaluate associations of maternal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GWG<\/jats:styled-content> with offspring asthma, overall and by subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Physician\u2010diagnosed asthma during childhood or adolescence was reported by 2694 children (21%). Maternal prepregnancy overweight (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.19, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.03\u20131.38) and obesity (1.34, 1.08\u20131.68) were associated with offspring asthma. In asthma subtype analyses, the association was seen only for asthma onset before age 12 years. Moreover, the association of maternal obesity with nonallergic asthma was observed in boys (2.39, 1.40\u20134.09) and not in girls (0.96, 0.50\u20131.85; <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = 0.03); the opposite pattern was suggested for allergic asthma. With regard to <jats:styled-content style=\"fixed-case\">GWG<\/jats:styled-content>, an association was suggested between gains of &lt;15 lb and higher risk of offspring asthma (1.28, 0.98\u20131.66), without clear allergy\u2010 or sex\u2010related patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relation of several prenatal factors to risk of childhood asthma supports the early origins hypothesis for asthma. The observed allergy\u2010 and sex\u2010specific patterns suggest multiple etiologic pathways.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12876","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T18:26:23Z","timestamp":1457807183000},"page":"1295-1304","source":"Crossref","is-referenced-by-count":80,"title":["Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma"],"prefix":"10.1111","volume":"71","author":[{"given":"O.","family":"Dumas","sequence":"first","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham &amp; Women's Hospital and Harvard Medical School Boston MA USA"},{"name":"Department of Emergency Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA"},{"name":"Inserm, VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"UVSQ UMR\u2010S 1168 Universit\u00e9 Versailles St\u2010Quentin\u2010en\u2010Yvelines Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Varraso","sequence":"additional","affiliation":[{"name":"Inserm, VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"UVSQ UMR\u2010S 1168 Universit\u00e9 Versailles St\u2010Quentin\u2010en\u2010Yvelines Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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