{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:29:24Z","timestamp":1790684964485,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01HS022728"],"award-info":[{"award-number":["R01HS022728"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The prevalence of drug allergies documented in electronic health records (\n                      <jats:styled-content style=\"fixed-case\">EHR<\/jats:styled-content>\n                      s) of large patient populations is understudied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We aimed to describe the prevalence of common drug allergies and patient characteristics documented in\n                      <jats:styled-content style=\"fixed-case\">EHR<\/jats:styled-content>\n                      s of a large healthcare network over the last two decades.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Drug allergy data were obtained from\n                      <jats:styled-content style=\"fixed-case\">EHR<\/jats:styled-content>\n                      s of patients who visited two large tertiary care hospitals in Boston from 1990 to 2013. The prevalence of each drug and drug class was calculated and compared by sex and race\/ethnicity. The number of allergies per patient was calculated and the frequency of patients having 1, 2, 3\u2026, or 10+ drug allergies was reported. We also conducted a trend analysis by comparing the proportion of each allergy to the total number of drug allergies over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1 766 328 patients, 35.5% of patients had at least one reported drug allergy with an average of 1.95 drug allergies per patient. The most commonly reported drug allergies in this population were to penicillins (12.8%), sulfonamide antibiotics (7.4%), opiates (6.8%), and nonsteroidal anti\u2010inflammatory drugs (\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s) (3.5%). The relative proportion of allergies to angiotensin\u2010converting enzyme (\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      ) inhibitors and\n                      <jats:styled-content style=\"fixed-case\">HMG<\/jats:styled-content>\n                      CoA reductase inhibitors (statins) have more than doubled since early 2000s. Drug allergies were most prevalent among females and white patients except for\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s,\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      inhibitors, and thiazide diuretics, which were more prevalent in black patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Females and white patients may be more likely to experience a reaction from common medications. An increase in reported allergies to\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      inhibitors and statins is noteworthy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.12881","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T13:32:36Z","timestamp":1457789556000},"page":"1305-1313","source":"Crossref","is-referenced-by-count":281,"title":["Drug allergies documented in electronic health records of a large healthcare system"],"prefix":"10.1111","volume":"71","author":[{"given":"L.","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine and Primary Care Brigham and Women's Hospital Boston MA USA"},{"name":"Clinical Informatics Partners eCare Partners HealthCare System Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dhopeshwarkar","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Primary Care Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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