{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:01Z","timestamp":1791274441327,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALK-Abell\u00f3 (Milan, Italy)"},{"name":"ThermoFisher Scientific (IgE assays)"},{"name":"TPS Production, Rome, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pollen\u2010food syndrome (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) is heterogeneous with regard to triggers, severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> based on IgE sensitization to panallergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 1271 Italian children (age 4\u201318 years) with seasonal allergic rhinoconjunctivitis (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>). Foods triggering <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts. IgE to panallergens Phl p 12 (profilin), Bet v 1 (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u201010), and Pru p 3 (ns<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>) were tested by Immuno<jats:styled-content style=\"fixed-case\">CAP FEIA<\/jats:styled-content>. An unsupervised hierarchical agglomerative clustering method was applied within <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> was observed in 300\/1271 children (24%). Cluster analysis identified five <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> endotypes linked to panallergen IgE sensitization: (i) cosensitization to \u22652 panallergens (\u2018multi\u2010panallergen <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019); (ii\u2013iv) sensitization to either profilin, or ns<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u201010 (\u2018mono\u2010panallergen <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019); (v) no sensitization to panallergens (\u2018no\u2010panallergen <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019). These endotypes showed peculiar characteristics: (i) \u2018multi\u2010panallergen <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019: severe disease with frequent allergic comorbidities and multiple offending foods; (ii) <jats:italic>\u2018<\/jats:italic>profilin <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019: oral allergy syndrome (<jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content>) triggered by <jats:italic>Cucurbitaceae<\/jats:italic>; (iii) \u2018<jats:styled-content style=\"fixed-case\">LTP PFS<\/jats:styled-content>\u2019: living in Southern Italy, <jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content> triggered by hazelnut and peanut; (iv) \u2018<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u201010 <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019: <jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content> triggered by <jats:italic>Rosaceae<\/jats:italic>; and (v) \u2018no\u2010panallergen <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\u2019: mild disease and <jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content> triggered by kiwifruit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a Mediterranean country characterized by multiple pollen exposures, <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> is a complex and frequent complication of childhood <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>, with five distinct endotypes marked by peculiar profiles of IgE sensitization to panallergens. Prospective studies in cohorts of patients with <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> are now required to test whether this novel classification may be useful for diagnostic and therapeutic purposes in the clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12888","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T02:20:51Z","timestamp":1458613251000},"page":"1181-1191","source":"Crossref","is-referenced-by-count":77,"title":["Endotypes of pollen\u2010food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification"],"prefix":"10.1111","volume":"71","author":[{"given":"C.","family":"Mastrorilli","sequence":"first","affiliation":[{"name":"Pediatric Department Department of Clinical and Experimental Medicine Azienda Ospedaliero\u2010Universitaria University of Parma Parma Italy"},{"name":"Department of Pediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit Sandro Pertini Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Caffarelli","sequence":"additional","affiliation":[{"name":"Pediatric Department Department of Clinical and Experimental Medicine Azienda Ospedaliero\u2010Universitaria University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Di Rienzo\u2010Businco","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit Sandro Pertini Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sfika","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit Sandro Pertini Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Asero","sequence":"additional","affiliation":[{"name":"Allergology Service San Carlo Clinic Paderno Dugnano, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dondi","sequence":"additional","affiliation":[{"name":"Pediatric Unit Department for Mother and Child Ramazzini Hospital Carpi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Pediatric Unit Mazzoni Hospital Ascoli Piceno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Povesi Dascola","sequence":"additional","affiliation":[{"name":"Pediatric Department Department of Clinical and Experimental Medicine Azienda Ospedaliero\u2010Universitaria University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Pediatric Unit Department of Medical and Surgical Sciences University of Bologna Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Pediatric Unit Department of Medical and Surgical Sciences University of Bologna Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maiello","sequence":"additional","affiliation":[{"name":"Pediatric Department Second University Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miraglia Del Giudice","sequence":"additional","affiliation":[{"name":"Pediatric Department Second University Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Frediani","sequence":"additional","affiliation":[{"name":"Pediatric Department La Sapienza University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Frediani","sequence":"additional","affiliation":[{"name":"Pediatric Department La Sapienza University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Pediatric Department La Sapienza University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pistoletti","sequence":"additional","affiliation":[{"name":"Pediatric Department La Sapienza University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Dello Iacono","sequence":"additional","affiliation":[{"name":"Pediatric Unit Fatebenefratelli Hospital Benevento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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