{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:03Z","timestamp":1791274443030,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D has immune\u2010modulating effects. We determined whether vitamin D supplementation during pregnancy and infancy prevents aeroallergen sensitization and primary care respiratory illness presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomized, double\u2010blind, placebo\u2010controlled parallel\u2010group trial. We assigned pregnant women, from 27\u2010week gestation to birth, and then their infants, from birth to 6 months, to placebo or one of two dosages of daily oral vitamin D. Woman\/infant pairs were randomized to: placebo\/placebo, 1000\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      \/400\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      or 2000\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      \/800\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      . When the children were 18 months old, we measured serum\u2010specific IgE antibodies and identified acute primary care visits described by the doctor to be due to a cold, otitis media, an upper respiratory infection, croup, asthma, bronchitis, bronchiolitis, a wheezy lower respiratory infection or fever and cough.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Specific IgE was measured on 185 of 260 (71%) enrolled children. The proportion of children sensitized differed by study group for four mite antigens:\n                      <jats:italic>Dermatophagoides farinae<\/jats:italic>\n                      (Der\u2010f1, Der\u2010f2) and\n                      <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>\n                      (Der\u2010p1, Der\u2010p2). With results presented for placebo, lower dose, and higher dose vitamin D, respectively (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05): Der\u2010f1 (18%, 10%, 2%), Der\u2010f2 (14%, 3%, 2%), Der\u2010p1 (19%, 14%, 3%) and Der\u2010p2 (12%, 2%, 3%). There were study group differences in the proportion of children with primary care visits described by the doctor as being for asthma (11%, 0%, 4%,\n                      <jats:italic>P =<\/jats:italic>\n                      0.002), but not for the other respiratory diagnoses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D supplementation during pregnancy and infancy reduces the proportion of children sensitized to mites at age 18 months. Preliminary data indicate a possible effect on primary care visits where asthma is diagnosed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.12909","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T10:07:12Z","timestamp":1460282832000},"page":"1325-1334","source":"Crossref","is-referenced-by-count":76,"title":["Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial"],"prefix":"10.1111","volume":"71","author":[{"given":"C. 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