{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:26:00Z","timestamp":1790717160882,"version":"4.1.0"},"reference-count":162,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Integrated Approaches to Food Allergen and Allergy Risk Management","award":["312147"],"award-info":[{"award-number":["312147"]}]},{"DOI":"10.13039\/501100000354","name":"UK Food Standards Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000354","id-type":"DOI","asserted-by":"crossref"}]},{"name":"TRACE study investigators","award":["FS241037"],"award-info":[{"award-number":["FS241037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anaphylaxis has been defined as a \u2018severe, life\u2010threatening generalized or systemic hypersensitivity reaction\u2019. However, data indicate that the vast majority of food\u2010triggered anaphylactic reactions are not life\u2010threatening. Nonetheless, severe life\u2010threatening reactions do occur and are unpredictable. We discuss the concepts surrounding perceptions of severe, life\u2010threatening allergic reactions to food by different stakeholders, with particular reference to the inclusion of clinical severity as a factor in allergy and allergen risk management. We review the evidence regarding factors that might be used to identify those at most risk of severe allergic reactions to food, and the consequences of misinformation in this regard. For example, a significant proportion of food\u2010allergic children also have asthma, yet almost none will experience a fatal food\u2010allergic reaction; asthma is not, in itself, a strong predictor for fatal anaphylaxis. The relationship between dose of allergen exposure and symptom severity is unclear. While dose appears to be a risk factor in at least a subgroup of patients, studies report that individuals with prior anaphylaxis do not have a lower eliciting dose than those reporting previous mild reactions. It is therefore important to consider severity and sensitivity as separate factors, as a highly sensitive individual will not necessarily experience severe symptoms during an allergic reaction. We identify the knowledge gaps that need to be addressed to improve our ability to better identify those most at risk of severe food\u2010induced allergic reactions.<\/jats:p>","DOI":"10.1111\/all.12924","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T08:31:52Z","timestamp":1462264312000},"page":"1241-1255","source":"Crossref","is-referenced-by-count":214,"title":["Can we identify patients at risk of life\u2010threatening allergic reactions to food?"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5161","authenticated-orcid":false,"given":"P. J.","family":"Turner","sequence":"first","affiliation":[{"name":"Section of Paediatrics (Allergy and Infectious Diseases) &amp; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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H.","family":"Gowland","sequence":"additional","affiliation":[{"name":"Allergy Action Farnborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Grabenhenrich","sequence":"additional","affiliation":[{"name":"Institute for Social Medicine Epidemiology and Health Economics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Food Standards Agency London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. F.","family":"Houben","sequence":"additional","affiliation":[{"name":"TNO Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"O'B Hourihane","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Muraro","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Centre for Food Allergy Diagnosis and Treatment University of Padua Veneto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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C.","family":"Remington","sequence":"additional","affiliation":[{"name":"TNO Zeist The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schnadt","sequence":"additional","affiliation":[{"name":"German Allergy and Asthma Association (Deutscher Allergie\u2010 und Asthmabund (DAAB)) M\u00f6nchengladbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van Ree","sequence":"additional","affiliation":[{"name":"Departments of Experimental Immunology and of Otorhinolaryngology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Venter","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Social Work University of Portsmouth Portsmouth UK"},{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Isle of Wight UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Worm","sequence":"additional","affiliation":[{"name":"Allergy\u2010Center Charit\u00e9 Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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