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Although allergies to cow's milk, egg, or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood. At present, there is no cure or treatment for food allergy that would result in an induction of tolerance to the symptom\u2010eliciting food. Avoidance, providing an emergency plan and education, is the standard of treatment. Oral immunotherapeutic approaches have been proven reasonable efficacy; however, they are associated with high rates of side\u2010effects and low numbers of patients achieving tolerance. Nevertheless, mechanisms that take place during oral immunotherapy may help to understand tolerance development. On the basis of these therapeutic interventions, events like loss of basophil activation and induction of regulatory lymphocyte subsets and of blocking antibodies have been described. Their functional importance at a clinical level, however, remains to be investigated in detail. Consequently, there is eminent need to understand the process of tolerance development to food allergens and define biomarkers to develop and monitor new treatment strategies for food allergy.<\/jats:p>","DOI":"10.1111\/all.12953","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T16:55:33Z","timestamp":1465577733000},"page":"1393-1404","source":"Crossref","is-referenced-by-count":28,"title":["Markers of tolerance development to food allergens"],"prefix":"10.1111","volume":"71","author":[{"given":"M.","family":"Ponce","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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