{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:06:34Z","timestamp":1782399994584,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Evidence suggests that specific allergen sensitizations are associated with different allergic diseases which may reflect different underlying immune profiles. We aimed to examine the cytokine profiles of individuals sensitized to eight common aeroallergens.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used data from the Tasmanian Longitudinal Health Study a population\u2010based cohort study of 45\u2010year\u2010olds. Serum cytokines (IL<\/jats:styled-content>\u20104, IL<\/jats:styled-content>\u20105, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20108, IL<\/jats:styled-content>\u201010, TNF<\/jats:styled-content>\u2010\u03b1) were measured in 1157 subjects using the LINCO<\/jats:styled-content>plex assays. Participants underwent skin prick testing for house dust mite, cat, grasses and moulds. Multivariable linear regression was used to compare serum cytokine levels between sensitized and nonatopic subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of allergic sensitization to any aeroallergen was 51% (95% CI<\/jats:styled-content> 47\u201354). Being sensitized to any aeroallergen was strongly associated with current asthma (OR<\/jats:styled-content> = 3.7, 95% CI<\/jats:styled-content> 2.6\u20135.3), and being sensitized to any moulds was associated with a very high risk of current asthma (OR = 6.40, 95% CI 4.06\u201310.1). The geometric mean (GM<\/jats:styled-content>) levels of Th2 cytokines (IL<\/jats:styled-content>\u20104, IL<\/jats:styled-content>\u20105 and IL<\/jats:styled-content>\u20106) for adults sensitized to Cladosporium<\/jats:italic> were significantly lower than the levels for nonatopic individuals (IL<\/jats:styled-content>\u20104 ratio of GM<\/jats:styled-content>s = 0.25, 95% CI<\/jats:styled-content> 0.10\u20130.62, P<\/jats:italic> = 0.003; IL<\/jats:styled-content>\u20105 GM<\/jats:styled-content> = 0.55, 95% CI<\/jats:styled-content> 0.30\u20130.99, P<\/jats:italic> = 0.05; and IL<\/jats:styled-content>\u20106 GM<\/jats:styled-content> = 0.50, 95% CI<\/jats:styled-content> 0.24\u20131.07, P<\/jats:italic> = 0.07). Individuals sensitized to other aeroallergens all showed elevated Th2 cytokine levels.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study is the first large population\u2010based study to demonstrate reduced Th2 cytokines levels in people sensitized to mould. Underlying biological mechanisms driving allergic inflammatory responses in adults sensitized to moulds may differ from those sensitized to other aeroallergens. These findings suggest that it may be necessary to tailor treatments in individuals sensitized to moulds compared with other aeroallergens in order to optimize outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12964","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T23:01:55Z","timestamp":1466636515000},"page":"1701-1711","source":"Crossref","is-referenced-by-count":6,"title":["Mould\u2010sensitized adults have lower Th2 cytokines and a higher prevalence of asthma than those sensitized to other aeroallergens"],"prefix":"10.1111","volume":"71","author":[{"given":"M. C.","family":"Matheson","sequence":"first","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"},{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Reece","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Kandane\u2010Rathnayake","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne Melbourne Vic. Australia"},{"name":"Department of Paediatrics The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H.","family":"Feather","sequence":"additional","affiliation":[{"name":"Gold Coast Hospital Southport Qld Australia"},{"name":"Bond University Varsity Lakes Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Southey","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tsimiklis","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Morrison","sequence":"additional","affiliation":[{"name":"University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"},{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Walters","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Vic. Australia"},{"name":"Menzies Research Institute Hobart Tas. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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