{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:37Z","timestamp":1761986497190},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"World Allergy Organization and the American College of Allergy, Asthma and Immunology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Europe, allergen extracts are standardized based on skin prick wheal size in 20\u201330 allergic subjects. To understand the biological activity of clinically effective <jats:styled-content style=\"fixed-case\">Sublingual immunotherapy<\/jats:styled-content>, we used this method to determine the biological activity of solution and tablet Timothy grass pollen (<jats:styled-content style=\"fixed-case\">TIM<\/jats:styled-content>) extracts, compared to an <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\u2010approved extract (Reference) of 10 000 BAU\/ml. Blinded, quadruplicate skin prick tests with concentrate and three serial half\u2010log dilutions allowed the construction of a semilogarithmic regression line per extract. Bioequivalent allergy units (<jats:styled-content style=\"fixed-case\">BAU<\/jats:styled-content>) values were obtained from the comparison with reference. Extracts and dilutions showed a neat linear dose response (all: <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> &gt; 0.98) in 33 rhinitis patients. Relative potencies: Staloral<jats:sup>\u00ae<\/jats:sup> 12 000 BAU\/ml, Soluprick<jats:sup>\u00ae<\/jats:sup> 10 300 BAU\/ml, Oralair<jats:sup>\u00ae<\/jats:sup> 8200 BAU, and Grazax<jats:sup>\u00ae<\/jats:sup> 6200 BAU. Even though all extract concentrates differed in wheal size (<jats:italic>P<\/jats:italic> = 0.01\u20130.001), Grazax<jats:sup>\u00ae<\/jats:sup> producing a 25% smaller wheal size than Oralair<jats:sup>\u00ae<\/jats:sup>, and the biological activity of these clinically effective <jats:styled-content style=\"fixed-case\">TIM<\/jats:styled-content> tablets led in the same range (6200\u20138200 <jats:styled-content style=\"fixed-case\">BAU<\/jats:styled-content>; 0.92\u20131.23 cm<jats:sup>2<\/jats:sup>). <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> dose\u2010finding studies for other pollens might start with allergen extracts producing 1.1 cm<jats:sup>2<\/jats:sup> wheal surface.<\/jats:p>","DOI":"10.1111\/all.12998","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:13:15Z","timestamp":1470215595000},"page":"1782-1786","source":"Crossref","is-referenced-by-count":8,"title":["Similar biological activity in skin prick test for Oralair<sup>\u00ae<\/sup> (8200 <scp>BAU<\/scp>) and Grazax<sup>\u00ae<\/sup> (6200 <scp>BAU<\/scp>) reinforces effective SLIT dosing level"],"prefix":"10.1111","volume":"71","author":[{"given":"D. E. S.","family":"Larenas Linnemann","sequence":"first","affiliation":[{"name":"Hospital M\u00e9dica Sur M\u00e9xico D.F. Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics, Informatics and Epidemiology Faculty of Medicine, University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rosario","sequence":"additional","affiliation":[{"name":"Universidad Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Esch","sequence":"additional","affiliation":[{"name":"Greer Laboratories Inc. Lenoir NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Matta","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional M\u00e9xico D.F. 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