{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:39:19Z","timestamp":1790451559807,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1111\/all.13005","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T04:16:37Z","timestamp":1471320997000},"page":"444-452","source":"Crossref","is-referenced-by-count":38,"title":["GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice"],"prefix":"10.1111","volume":"72","author":[{"given":"T.","family":"Rubi\u0107-Schneider","sequence":"first","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"},{"name":"Former NIBR; Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Carballido-Perrig","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"},{"name":"Former NIBR; Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Regairaz","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Raad","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jost","sequence":"additional","affiliation":[{"name":"Former NIBR; Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rauld","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Christen","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kreutzer","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lametschwandner","sequence":"additional","affiliation":[{"name":"Former NIBR; Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Littlewood-Evans","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Carballido","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research (NIBR); Basel Switzerland"},{"name":"Former NIBR; Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"10.1111\/all.13005-BIB0001|all13005-cit-0001","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0065-2571(70)90028-2","article-title":"Rate control of the tricarboxylic acid cycle","volume":"8","author":"Krebs","year":"1970","journal-title":"Adv Enzyme Regul"},{"key":"10.1111\/all.13005-BIB0002|all13005-cit-0002","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nature02488","article-title":"Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors","volume":"429","author":"He","year":"2004","journal-title":"Nature"},{"key":"10.1111\/all.13005-BIB0003|all13005-cit-0003","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fendo.2012.00022","article-title":"The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions","volume":"3","author":"Ariza","year":"2012","journal-title":"Front Endocrinol"},{"key":"10.1111\/all.13005-BIB0004|all13005-cit-0004","doi-asserted-by":"crossref","first-page":"427","DOI":"10.18632\/aging.100563","article-title":"Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions","volume":"5","author":"Favret","year":"2013","journal-title":"Aging"},{"key":"10.1111\/all.13005-BIB0005|all13005-cit-0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/ATVBAHA.113.302131","article-title":"G-protein-coupled receptor 91 and succinate are key contributors in neonatal postcerebral hypoxia-ischemia recovery","volume":"34","author":"Hamel","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/all.13005-BIB0006|all13005-cit-0006","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nm.1873","article-title":"The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis","volume":"14","author":"Sapieha","year":"2008","journal-title":"Nat Med"},{"key":"10.1111\/all.13005-BIB0007|all13005-cit-0007","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1167\/iovs.10-6722","article-title":"Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium","volume":"52","author":"Gnana-Prakasam","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1111\/all.13005-BIB0008|all13005-cit-0008","first-page":"5415","article-title":"Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy","volume":"7","author":"Yang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1111\/all.13005-BIB0009|all13005-cit-0009","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12964-014-0078-2","article-title":"Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation","volume":"12","author":"Aguiar","year":"2014","journal-title":"Cell Commun Signal"},{"key":"10.1111\/all.13005-BIB0010|all13005-cit-0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jhep.2007.03.016","article-title":"Succinate is a paracrine signal for liver damage","volume":"47","author":"Correa","year":"2007","journal-title":"J Hepatol"},{"key":"10.1111\/all.13005-BIB0011|all13005-cit-0011","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbrc.2015.06.023","article-title":"Succinate causes \u03b1-SMA production through GPR91 activation in hepatic stellate cells","volume":"463","author":"Li","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/all.13005-BIB0012|all13005-cit-0012","first-page":"1209","article-title":"Circulating succinate is elevated in rodent models of hypertension and metabolic disease","volume":"20","author":"Sadagopan","year":"2007","journal-title":"Am J Hypertens"},{"key":"10.1111\/all.13005-BIB0013|all13005-cit-0013","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/ki.2010.333","article-title":"High glucose and renin release: the role of succinate and GPR91","volume":"78","author":"Peti-Peterdi","year":"2010","journal-title":"Kidney Int"},{"key":"10.1111\/all.13005-BIB0014|all13005-cit-0014","first-page":"2526","article-title":"Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney","volume":"118","author":"Toma","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/all.13005-BIB0015|all13005-cit-0015","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1681\/ASN.2008070740","article-title":"Activation of the succinate receptor GPR91 in macula densa cells causes renin release","volume":"20","author":"Vargas","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/all.13005-BIB0016|all13005-cit-0016","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ni.1657","article-title":"Triggering the succinate receptor GPR91 on dendritic cells enhances immunity","volume":"9","author":"Rubic","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1111\/all.13005-BIB0017|all13005-cit-0017","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1167\/iovs.12-9662","article-title":"The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes","volume":"53","author":"Mattapallil","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1111\/all.13005-BIB0018|all13005-cit-0018","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1523-1747.2003.12331.x","article-title":"Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A1","volume":"121","author":"Meingassner","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1111\/all.13005-BIB0019|all13005-cit-0019","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.0022-202x.2001.01626.x","article-title":"Topical peroxisome proliferator activated receptor-\u03b1 activators reduce inflammation in irritant and allergic contact dermatitis models","volume":"118","author":"Sheu","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1111\/all.13005-BIB0020|all13005-cit-0020","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.4049\/jimmunol.180.5.3457","article-title":"Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice","volume":"180","author":"Graf","year":"2008","journal-title":"J Immunol"},{"key":"10.1111\/all.13005-BIB0021|all13005-cit-0021","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.4049\/jimmunol.169.9.4788","article-title":"Long-lived Th2 memory in experimental allergic asthma","volume":"169","author":"Mojtabavi","year":"2002","journal-title":"J Immunol"},{"key":"10.1111\/all.13005-BIB0022|all13005-cit-0022","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/art.24552","article-title":"The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation","volume":"60","author":"Koziczak-Holbro","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1111\/all.13005-BIB0023|all13005-cit-0023","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1021\/jm501052c","article-title":"G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonists reduce the production of proinflammatory cytokines and stabilize the alternative macrophage phenotype","volume":"57","author":"H\u00f6genauer","year":"2014","journal-title":"J Med Chem"},{"key":"10.1111\/all.13005-BIB0024|all13005-cit-0024","first-page":"Unit 7.37","article-title":"Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood","volume":"Chapter 7","author":"R\u00e5dinger","year":"2010","journal-title":"Curr Protoc Immunol"},{"key":"10.1111\/all.13005-BIB0025|all13005-cit-0025","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/all.13005-BIB0026|all13005-cit-0026","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00251-010-0452-1","article-title":"Chronic allergen challenge induces bronchial mast cell accumulation in BALB\/c but not C57BL\/6 mice and is independent of IL-9","volume":"62","author":"Pae","year":"2010","journal-title":"Immunogenetics"},{"key":"10.1111\/all.13005-BIB0027|all13005-cit-0027","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80045-X","article-title":"From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins","volume":"10","author":"Korganow","year":"1999","journal-title":"Immunity"},{"key":"10.1111\/all.13005-BIB0028|all13005-cit-0028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1084\/jem.20020439","article-title":"Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis","volume":"196","author":"Ji","year":"2002","journal-title":"J Exp Med"},{"key":"10.1111\/all.13005-BIB0029|all13005-cit-0029","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(02)00275-3","article-title":"Arthritis critically dependent on innate immune system players","volume":"16","author":"Ji","year":"2002","journal-title":"Immunity"},{"key":"10.1111\/all.13005-BIB0030|all13005-cit-0030","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.4049\/jimmunol.169.11.6604","article-title":"The role of FcgammaR signaling in the K\/B x N serum transfer model of arthritis","volume":"169","author":"Corr","year":"2002","journal-title":"J Immunol"},{"key":"10.1111\/all.13005-BIB0031|all13005-cit-0031","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1126\/science.1073176","article-title":"Mast cells: a cellular link between autoantibodies and inflammatory arthritis","volume":"297","author":"Lee","year":"2002","journal-title":"Science"},{"key":"10.1111\/all.13005-BIB0032|all13005-cit-0032","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/art.1780200314","article-title":"Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice","volume":"20","author":"Brackertz","year":"1977","journal-title":"Arthritis Rheum"},{"key":"10.1111\/all.13005-BIB0033|all13005-cit-0033","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/eji.200526167","article-title":"A crucial role for macrophages in the pathology of K\/B x N serum-induced arthritis","volume":"35","author":"Solomon","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1111\/all.13005-BIB0034|all13005-cit-0034","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"J Immunol"},{"key":"10.1111\/all.13005-BIB0035|all13005-cit-0035","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1038\/sj.onc.1209594","article-title":"Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer","volume":"25","author":"King","year":"2006","journal-title":"Oncogene"},{"key":"10.1111\/all.13005-BIB0036|all13005-cit-0036","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1073\/pnas.97.6.2826","article-title":"Mitochondrial dysfunction during hypoxia\/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates","volume":"97","author":"Weinberg","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/all.13005-BIB0037|all13005-cit-0037","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1111\/all.13005-BIB0038|all13005-cit-0038","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1111\/all.13005-BIB0039|all13005-cit-0039","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J Exp Med"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/all.13005\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T22:10:04Z","timestamp":1625436604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,12]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1111\/all.13005","archive":["Portico"],"relation":{},"ISSN":["0105-4538"],"issn-type":[{"value":"0105-4538","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,12]]}}}