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The underlying clinical endpoints are analysed in seasonal time periods predefined based on the background pollen concentration. However, any validated or generally accepted definition from academia or regulatory authorities for this relevant pollen exposure intensity or period of time (season) is currently not available. Therefore, this Task Force initiative of the European Academy of Allergy and Clinical Immunology (\n                      <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\n                      ) aimed to propose definitions based on expert consensus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A Task Force of the Immunotherapy and Aerobiology and Pollution Interest Groups of the\n                      <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\n                      reviewed the literature on pollen exposure in the context of defining relevant time intervals for evaluation of efficacy in AIT trials. Underlying principles in measuring pollen exposure and associated methodological problems and limitations were considered to achieve a consensus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Task Force achieved a comprehensive position in defining pollen exposure times for different pollen types. Definitions are presented for \u2018pollen season\u2019, \u2018high pollen season\u2019 (or \u2018peak pollen period\u2019) and \u2018high pollen days\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This\n                      <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\n                      position paper provides definitions of pollen exposures for different pollen types for use in AIT trials. Their validity as standards remains to be tested in future studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13092","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T06:26:48Z","timestamp":1479796008000},"page":"713-722","source":"Crossref","is-referenced-by-count":185,"title":["Defining pollen exposure times for clinical trials of allergen immunotherapy for pollen\u2010induced rhinoconjunctivitis \u2013 an\n                    <scp>EAACI<\/scp>\n                    position paper"],"prefix":"10.1111","volume":"72","author":[{"given":"O.","family":"Pfaar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Medical Faculty Mannheim Universit\u00e4tsmedizin Mannheim Heidelberg University Mannheim Germany"},{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bastl","sequence":"additional","affiliation":[{"name":"Aerobiology and Pollen Information Research Unit Department of Oto\u2010Rhino\u2010Laryngology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Berger","sequence":"additional","affiliation":[{"name":"Aerobiology and Pollen Information Research Unit Department of Oto\u2010Rhino\u2010Laryngology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buters","sequence":"additional","affiliation":[{"name":"ZAUM Center of Allergy &amp; Environment Helmholtz Center Munich\/Technische Universit\u00e4t M\u00fcnchen Member of the German Center for Lung Research (DZL) Munich Germany"},{"name":"K\u00fchne Foundation Christine K\u00fchne\u2010Center for Allergy Research and Education (CK\u2010CARE) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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