{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:15:09Z","timestamp":1792476909220,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the Learning Early About Peanut Allergy (<jats:styled-content style=\"fixed-case\">LEAP<\/jats:styled-content>) study, early peanut introduction in high\u2010risk 4\u2010 to 11\u2010month\u2010olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high\u2010risk factors on peanut tolerance are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary analysis was conducted on the publically available <jats:styled-content style=\"fixed-case\">LEAP<\/jats:styled-content> dataset, exploring relationships between peanut tolerance, baseline peanut\/egg sensitization, eczema severity\/duration, age of introduction, gender, and race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A multiple logistic regression model predicting odds of successful oral food challenge (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>) at 60 months noted higher odds with early introduction (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 9.2, <jats:italic>P<\/jats:italic> &lt; 0.001, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.2\u201320.3), white race (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.1, <jats:italic>P<\/jats:italic> = 0.04, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20133.9), and advancing age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.8, <jats:italic>P<\/jats:italic> = 0.04, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u201320.8). Odds of peanut tolerance were lower with increasing peanut wheal size (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.58, <jats:italic>P<\/jats:italic> &lt; 0.001, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.46\u20130.74), increased baseline <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.98, <jats:italic>P<\/jats:italic> = 0.04, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.97\u20131), and increased kU<jats:sub>A<\/jats:sub>\/l of egg serum IgE (sIgE) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.99, <jats:italic>P<\/jats:italic> = 0.04, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.98\u20131). The probability of peanut tolerance in the early introduction group was 83% <jats:italic>vs<\/jats:italic> 43% in the avoidance group with <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> wheal of &lt;4 mm. The probability of a successful <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> was significantly higher with peanut introduction between 6 and 11 months than at 4\u20136 months. Increasing eczema severity had limited impact on the probability of peanut tolerance in the early introduction arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increasing peanut wheal size predicted peanut tolerance only in the avoidance arm. Peanut introduction between 6 and 11 months of age was associated with the highest rates of peanut tolerance, questioning the \u2018urgency\u2019 of introduction before 6 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13100","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T09:08:34Z","timestamp":1480410514000},"page":"1254-1260","source":"Crossref","is-referenced-by-count":31,"title":["<scp>LEAP<\/scp>ing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction"],"prefix":"10.1111","volume":"72","author":[{"given":"M.","family":"Greenhawt","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Allergy Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Fleischer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Allergy Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics British Columbia Children's Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Venter","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Stukus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Allergy and Immunology Nationwide Children's Hospital and The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ann and Robert H. Lurie Children's Hospital of Chicago Northwestern Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Spergel","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Pediatrics The Children's Hospital of Philadelphia Perelman School of Medicine at University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.050"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.029"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02176.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12616"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.001"},{"key":"e_1_2_9_14_1","unstructured":"https:\/\/www.itntrialshare.org\/(accessed 5 December 2015)."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.12.016"},{"key":"e_1_2_9_16_1","first-page":"2164","article-title":"Peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Greenhawt M","year":"2015","journal-title":"N Engl J Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2015.07.010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60305-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1500186"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0646E"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1322"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.028"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12090"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2012.09.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815584927"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.002"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:49:06Z","timestamp":1696502946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,22]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/all.13100"],"URL":"https:\/\/doi.org\/10.1111\/all.13100","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,22]]}}}