{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:45:35Z","timestamp":1791585935312,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007037","name":"Ministeriet Sundhed Forebyggelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic low\u2010grade inflammation has been demonstrated in a range of the frequent noncommunicable diseases (<jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>s) proposing a shared mechanism, but is largely unexplored in relation to allergic sensitization. We therefore aimed to investigate the possible association with childhood allergic sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), interleukin\u20101\u03b2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, tumor necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1), and chemokine (C\u2010X\u2010C motif) ligand 8 (<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8) were measured in plasma at age 6 months (<jats:italic>N<\/jats:italic> = 214) and 7 years (<jats:italic>N<\/jats:italic> = 277) in children from the Copenhagen Prospective Studies on Asthma in Childhood<jats:sub>2000<\/jats:sub> (<jats:styled-content style=\"fixed-case\">COPSAC<\/jats:styled-content><jats:sub>2000<\/jats:sub>) birth cohort. Allergic sensitization against common inhalant and food allergens was determined longitudinally at ages \u00bd, 1\u00bd, 4 and 6 years by specific IgE assessments and skin prick tests. Associations between inflammatory biomarkers and sensitization phenotypes were tested with logistic regression and principal component analyses (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted for gender, recent infections, and a <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> genetic risk score, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> at 7 years was associated with concurrent elevated specific IgE against any allergen [adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) = 1.40; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.14\u20131.72; <jats:italic>P<\/jats:italic> = 0.001], aeroallergens (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.43; 1.15\u20131.77; <jats:italic>P<\/jats:italic> = 0.001), food allergens (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.31; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.02\u20131.67; <jats:italic>P<\/jats:italic> = 0.04), sensitization without any clinical allergy symptoms (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.40; 1.06\u20131.85; <jats:italic>P<\/jats:italic> = 0.02), and with similar findings for skin prick tests. The other inflammatory markers were not univariately associated with sensitization, but multiparametric <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> suggested a specific inflammatory response among sensitized children. Inflammatory markers at age 6 months were not associated with subsequent development of sensitization phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> is associated with allergic sensitization in school\u2010aged children suggesting systemic low\u2010grade inflammation as a phenotypic characteristic of this early\u2010onset <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13108","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T22:56:38Z","timestamp":1482188198000},"page":"1073-1080","source":"Crossref","is-referenced-by-count":24,"title":["Allergic sensitization at school age is a systemic low\u2010grade inflammatory disorder"],"prefix":"10.1111","volume":"72","author":[{"given":"B. L.","family":"Chawes","sequence":"first","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stokholm","sequence":"additional","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Department of Pediatrics Naestved Hospital Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010M. M.","family":"Schoos","sequence":"additional","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. R.","family":"Fink","sequence":"additional","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brix","sequence":"additional","affiliation":[{"name":"Department of Systems Biology Center for Biological Sequence Analysis Technical University of Denmark Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bisgaard","sequence":"additional","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001206"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0411-273"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202244109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649939"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077655"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5732"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00114405"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61398-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054692"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052632"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201101-0111OC"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00936.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12523"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02085.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.026"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.948570"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.020"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00465-10"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2694"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2686"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3461"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00456.x"},{"key":"e_1_2_11_27_1","unstructured":"PubMed entry.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16707391(accessed 15 April 2014)."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3386"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-10-52"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.1126"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-014-9658-6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12072"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2397"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12291"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.060"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334150"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.18318"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:06:08Z","timestamp":1696388768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/all.13108"],"URL":"https:\/\/doi.org\/10.1111\/all.13108","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}