{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:24:06Z","timestamp":1776752646643,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EuroPrevall","award":["FP6-FOOD-CT-2005-514000"],"award-info":[{"award-number":["FP6-FOOD-CT-2005-514000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish\u2010borne helminth <jats:italic>Opishorchis felineus<\/jats:italic> and specific IgE, skin prick testing, and atopic symptoms in Western Siberia, with lifestyle and hygiene standards of a developed country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Schoolchildren aged 7\u201311 years were sampled from one urban and two rural regions. Skin prick tests (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) and specific IgE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) against food and aeroallergens were measured, and data on allergic symptoms and on demographic and socioeconomic factors were collected by questionnaire. Diagnosis of opisthorchiasis was based on <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> performed on stool samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 732 children included, 34.9% had opisthorchiasis. The sensitization to any allergen when estimated by positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> was 12.8%, while much higher, 24.0%, when measured by <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>. Atopic symptoms in the past year (flexural eczema and\/or rhinoconjunctivitis) were reported in 12.4% of the children. <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> was positively related to flexural eczema and rhinoconjunctivitis, but not to wheezing. Opisthorchiasis showed association with lower <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> response, as well as borderline association with low IgE reactivity to any allergen. However, the effect of opisthorchiasis on <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> response was not mediated by IgE, suggesting that opisthorchiasis influences <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> response through another mechanism. Opisthorchiasis also showed borderline association with lower atopic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a negative association between a chronic helminth infection and skin prick test reactivity even in a developed country.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13120","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T07:52:39Z","timestamp":1482997959000},"page":"1096-1104","source":"Crossref","is-referenced-by-count":17,"title":["<i>Opisthorchis felineus<\/i> negatively associates with skin test reactivity in Russia\u2014EuroPrevall\u2010International Cooperation study"],"prefix":"10.1111","volume":"72","author":[{"given":"O. S.","family":"Fedorova","sequence":"first","affiliation":[{"name":"Department of Faculty Pediatrics Siberian State Medical University Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-5881","authenticated-orcid":false,"given":"J. J.","family":"Janse","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Ogorodova","sequence":"additional","affiliation":[{"name":"Department of Faculty Pediatrics Siberian State Medical University Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Fedotova","sequence":"additional","affiliation":[{"name":"Department of Faculty Pediatrics Siberian State Medical University Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Achterberg","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Cl\u00ednico San Carlos IdISSC Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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