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Several studies suggest that <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s in murine models lacking T and B cells induces eosinophilia and airway hyper\u2010reactivity (<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>), which are cardinal features of asthma. More importantly, numerous recent studies have highlighted the role of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s in asthma persistence and exacerbation among human subjects, and thus, regulation of pulmonary <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s is a major area of investigation aimed at curbing allergic lung inflammation and exacerbation. Emerging evidence reveals that a group of regulatory T cells, induced Tregs (<jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs), effectively suppress the production of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2\u2010driven, pro\u2010inflammatory cytokines <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013. The inhibitory effects of <jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs are blocked by preventing direct cellular contact or by inhibiting the <jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content>\u2010ligand (<jats:styled-content style=\"fixed-case\">ICOSL<\/jats:styled-content>) pathway, suggesting that both direct contact and <jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICOSL<\/jats:styled-content> interaction are important in the regulation of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 function. Also, cytokines such as <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 significantly reduce cytokine secretion by <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s. Altogether, these new findings uncover <jats:styled-content style=\"fixed-case\">iT<\/jats:styled-content>regs as potent regulators of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 activation and implicate their utility as a therapeutic approach for the treatment of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2\u2010mediated allergic asthma and respiratory disease.<\/jats:p>","DOI":"10.1111\/all.13139","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T07:12:39Z","timestamp":1486192359000},"page":"1148-1155","source":"Crossref","is-referenced-by-count":86,"title":["Regulatory T cells and type 2 innate lymphoid cell\u2010dependent asthma"],"prefix":"10.1111","volume":"72","author":[{"given":"J. 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