{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:09:15Z","timestamp":1793333355259,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality\u2010of\u2010life characteristics in adult patients with a first\u2010time diagnosis of rhinitis and\/or asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two sequential, identically designed studies were carried out to evaluate such associations (<jats:styled-content style=\"fixed-case\">PERFILAR<\/jats:styled-content> I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">PERFILAR II<\/jats:styled-content> was an extension of <jats:styled-content style=\"fixed-case\">PERFILAR<\/jats:styled-content> I with additional allergens being included. Both phases were epidemiological, descriptive, cross\u2010sectional, nonintervention multicenter studies. Participants were required to have lived for at least the last 2\u00a0years in the geographical zone. Asthma control assessment was based on <jats:styled-content style=\"fixed-case\">ACQ<\/jats:styled-content>\u20105. Health\u2010related quality of life was evaluated with validated scales for rhinitis (<jats:styled-content style=\"fixed-case\">ESPRINT<\/jats:styled-content>\u201015) and asthma (Mini\u2010<jats:styled-content style=\"fixed-case\">AQLQ<\/jats:styled-content>). Skin prick tests were used to identify sensitization to involved allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 301 physicians recruited 2711 patients for <jats:styled-content style=\"fixed-case\">PERFILAR<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Sensitization to allergens was significantly different in patients with rhinitis with\/without asthma. Seasonal allergens were associated with rhinitis, a longer time to asthma development, and more severe and commonly intermittent rhinitis. <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content> were associated with more common rhinitis, and Alternaria was associated with asthma. The study confirms an association of geographical areas with relevant allergens and allergic clinical picture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Different types of aeroallergens and specific sensitization profiles are associated with different allergic clinical pictures (rhinitis with\/without asthma), different clinical symptoms, and different levels of severity. This could have implications to predict later clinical course and to select appropriate management approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13141","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T22:06:53Z","timestamp":1487282813000},"page":"1306-1316","source":"Crossref","is-referenced-by-count":40,"title":["Allergic respiratory disease: Different allergens, different symptoms"],"prefix":"10.1111","volume":"72","author":[{"given":"A.","family":"Valero","sequence":"first","affiliation":[{"name":"Pneumology and Allergy Department Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Quirce","sequence":"additional","affiliation":[{"name":"Department of Allergy Healthcare Research Institute IdiPAZ CIBER de Enfermedades Respiratorias CIBERES Hospital Universitario La Paz Madrid 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