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However, little is known about the combined role of airway microbiota and <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age &lt;1\u00a0year) hospitalized for bronchiolitis during 2011\u20102014, we observed statistically significant interactions between nasopharyngeal airway <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 levels and microbiota profiles with regard to the risk of both intensive care use (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>=.02) and hospital length\u2010of\u2010stay \u22653\u00a0days (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>=.03). Among infants with lower <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 levels, the <jats:italic>Haemophilus<\/jats:italic>\u2010dominant microbiota profile was associated with a higher risk of intensive care use (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.20; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.18\u20108.68; <jats:italic>P<\/jats:italic>=.02) and hospital length\u2010of\u2010stay \u22653\u00a0days (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 4.14; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.08\u20108.24; <jats:italic>P<\/jats:italic>&lt;.001) compared to the <jats:italic>Moraxella<\/jats:italic>\u2010dominant profile. Conversely, among those with higher <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 levels, there were no significant associations between the microbiota profiles and these severity outcomes (all <jats:italic>P<\/jats:italic>\u2265.10).<\/jats:p>","DOI":"10.1111\/all.13160","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T15:37:56Z","timestamp":1489765076000},"page":"1796-1800","source":"Crossref","is-referenced-by-count":28,"title":["The relationship between nasopharyngeal <scp>CCL<\/scp>5 and microbiota on disease severity among infants with bronchiolitis"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-7999","authenticated-orcid":false,"given":"K.","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Mansbach","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Ajami","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research Department of Molecular Virology and Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F","family":"Petrosino","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research Department of Molecular Virology and Microbiology Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Freishtat","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Department of Pediatrics Children's National Health System Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Teach","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Department of Pediatrics Children's National Health System Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Piedra","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology and Pediatrics Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"C. A.","family":"Camargo\u00a0","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3877"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0220OC"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00152-2016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.12.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307575110"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0325OC"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0182-1"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:01:22Z","timestamp":1693195282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/all.13160"],"URL":"https:\/\/doi.org\/10.1111\/all.13160","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}