{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:26:56Z","timestamp":1789586816344,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,21]],"date-time":"2017-05-21T00:00:00Z","timestamp":1495324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Precision medicine (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> within existing adult treatment algorithms for allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) and chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second\u2010level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long\u2010term therapeutic strategy. Endotype\u2010driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment.<\/jats:p>","DOI":"10.1111\/all.13162","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T15:36:30Z","timestamp":1489764990000},"page":"1297-1305","source":"Crossref","is-referenced-by-count":142,"title":["Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis \u2013 A <scp>EUFOREA<\/scp>\u2010<scp>ARIA<\/scp>\u2010<scp>EPOS<\/scp>\u2010<scp>AIRWAYS ICP<\/scp> statement"],"prefix":"10.1111","volume":"72","author":[{"given":"P. W.","family":"Hellings","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery UZ Leuven Leuven Belgium"},{"name":"Department of Otorhinolaryngology Academic Medical Center Amsterdam The Netherlands"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Upper Airways Research Laboratory Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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A.","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) Christine\u2010K\u00fchne Center for Allergy Research and Education University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bieber","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Christine K\u00fchne\u2010Center for Allergy Research and Education Friedrich\u2010Wilhelms\u2010University Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Agache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Transylvania University Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bernal\u2010Sprekelsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Cl\u00ednic Universitari Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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