{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:11:40Z","timestamp":1781842300596,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WO 541\/16\u20101"],"award-info":[{"award-number":["WO 541\/16\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaphylaxis is a life\u2010threatening hypersensitivity reaction. To identify biomarkers for the condition, we assessed serum levels of apolipoprotein (Apo)A and ApoE. We found a reduction of both lipoproteins in anaphylactic mice as well as in orally challenged food allergic patients. We then compared patients after acute anaphylaxis with several control groups (nonallergic, history of allergen\u2010triggered anaphylaxis, acute cardiovascular\/febrile reactions). In this unpaired setting, ApoE levels were unaltered, while ApoA1 was reduced in the anaphylactic group. Although unable to discriminate between anaphylaxis and cardiovascular\/febrile reactions, <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve analysis revealed a reasonably high area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) of 0.91 for ApoA1. Serum 9\u03b1,11\u00df\u2010<jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content><jats:sub>2<\/jats:sub>, recently identified as a suitable biomarker for anaphylaxis, outperformed ApoA1 with <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=0.95. Intriguingly however its power further increased upon combination of both mediators reaching <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=1<jats:sub>.<\/jats:sub> Our data suggest that ApoA1 combined with 9\u03b1,11\u00df\u2010<jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content><jats:sub>2<\/jats:sub> represents a useful composite biomarker of anaphylaxis, achieving superior diagnostic power over either factor alone.<\/jats:p>","DOI":"10.1111\/all.13176","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T18:41:20Z","timestamp":1491417680000},"page":"1801-1805","source":"Crossref","is-referenced-by-count":19,"title":["Serum levels of 9\u03b1,11\u03b2\u2010<scp>PGF<\/scp><sub>2<\/sub> and apolipoprotein A1 achieve high predictive power as biomarkers of anaphylaxis"],"prefix":"10.1111","volume":"72","author":[{"given":"M.","family":"Wittenberg","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Allergy Center Charit\u00e9, CCM Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergy Center Charit\u00e9, CCM Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Francuzik","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergy Center Charit\u00e9, CCM Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Proteome Factory AG Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Babina","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy 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