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The aims of this study were (i) to examine fatty acid levels and their metabolism in obese and nonobese asthma patients and (ii) to determine the functional effects of altered fatty acid metabolism in experimental models.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Medium\u2010 and long\u2010chain fatty acid levels were quantified in serum from 161 human volunteers by\n LC<\/jats:styled-content>\n \/\n MS<\/jats:styled-content>\n . Changes in stearoyl\u2010coenzyme A desaturase (\n SCD<\/jats:styled-content>\n ) expression and activity were evaluated in the ovalbumin (\n OVA<\/jats:styled-content>\n ) and house dust mite (\n HDM<\/jats:styled-content>\n ) murine models. Primary human bronchial epithelial cells from asthma patients and controls were evaluated for\n SCD<\/jats:styled-content>\n expression and activity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The serum desaturation index (an indirect measure of\n SCD<\/jats:styled-content>\n ) was significantly reduced in nonobese asthma patients and in the\n OVA<\/jats:styled-content>\n murine model.\n \n SCD<\/jats:styled-content>\n 1\n <\/jats:italic>\n gene expression was significantly reduced within the lungs following\n OVA<\/jats:styled-content>\n or\n HDM<\/jats:styled-content>\n challenge. Inhibition of\n SCD<\/jats:styled-content>\n in mice promoted airway hyper\u2010responsiveness.\n \n SCD<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression was suppressed in bronchial epithelial cells from asthma patients.\n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201013 reduced epithelial cell\n \n SCD<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression. Inhibition of\n SCD<\/jats:styled-content>\n reduced surfactant protein C expression and suppressed rhinovirus\u2010induced\n IP<\/jats:styled-content>\n \u201010 secretion, which was associated with increased viral titers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the first study to demonstrate decreased fatty acid desaturase activity in humans with asthma. Experimental models in mice and human epithelial cells suggest that inhibition of desaturase activity leads to airway hyper\u2010responsiveness and reduced antiviral defense.\n SCD<\/jats:styled-content>\n may represent a new target for therapeutic intervention in asthma patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13180","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T03:13:27Z","timestamp":1491880407000},"page":"1744-1752","source":"Crossref","is-referenced-by-count":37,"title":["Altered fatty acid metabolism and reduced stearoyl\u2010coenzyme a desaturase activity in asthma"],"prefix":"10.1111","volume":"72","author":[{"given":"N.","family":"Rodriguez\u2010Perez","sequence":"first","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos 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