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However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>), in relation to other biomarkers and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum periostin was examined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> in 1100 subjects aged 17\u201076 from the Swedish Global Allergy and Asthma European Network (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>(2)<jats:styled-content style=\"fixed-case\">LEN<\/jats:styled-content>) study, which included 463 asthmatics with\/without chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>), 98 individuals with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), IgE, urinary eosinophil\u2010derived neurotoxin (U\u2010<jats:styled-content style=\"fixed-case\">EDN<\/jats:styled-content>), and serum eosinophil cationic protein (S\u2010<jats:styled-content style=\"fixed-case\">ECP<\/jats:styled-content>), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, U\u2010<jats:styled-content style=\"fixed-case\">EDN<\/jats:styled-content>, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) related to higher periostin levels in subjects both with and without asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype\u2010specific biomarker in asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13181","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T14:40:23Z","timestamp":1491921623000},"page":"1753-1760","source":"Crossref","is-referenced-by-count":64,"title":["Serum periostin relates to type\u20102 inflammation and lung function in asthma: Data from the large population\u2010based cohort Swedish <scp>GA<\/scp>(2)<scp>LEN<\/scp>"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-8419","authenticated-orcid":false,"given":"A.","family":"James","sequence":"first","affiliation":[{"name":"Experimental Asthma and Allergy Research National Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Respiratory, Allergy and Sleep Research Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Malinovschi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Physiology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Holweg","sequence":"additional","affiliation":[{"name":"Genentech Inc South San Fransisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ono","sequence":"additional","affiliation":[{"name":"Shino\u2010test Corporation Ltd. 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