{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:03Z","timestamp":1740124323099,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004344","name":"Stichting Astma Bestrijding","doi-asserted-by":"publisher","award":["SAB 2006\/018"],"award-info":[{"award-number":["SAB 2006\/018"]}],"id":[{"id":"10.13039\/501100004344","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wheezing is common in childhood. However, current prediction models of pediatric asthma have only modest accuracy. Novel biomarkers and definition of subphenotypes may improve asthma prediction. <jats:italic>Interleukin\u20101\u2010receptor\u2010like\u20101<\/jats:italic> (<jats:italic>IL1RL1<\/jats:italic> or <jats:italic>ST2<\/jats:italic>) is a well\u2010replicated asthma gene and associates with eosinophilia. We investigated whether serum <jats:styled-content style=\"fixed-case\">sST<\/jats:styled-content>2 predicts asthma and asthma with elevated exhaled <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> (Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), compared to the commonly used Asthma Prediction Index (<jats:styled-content style=\"fixed-case\">API<\/jats:styled-content>). Using logistic regression modeling, we found that serum <jats:styled-content style=\"fixed-case\">sST<\/jats:styled-content>2 levels in 2\u20103 years\u2010old wheezers do not predict doctors\u2019 diagnosed asthma at age 6 years. Instead, <jats:styled-content style=\"fixed-case\">sST<\/jats:styled-content>2 predicts a subphenotype of asthma characterized by increased levels of Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, a marker for eosinophilic airway inflammation. Herein, <jats:styled-content style=\"fixed-case\">sST<\/jats:styled-content>2 improved the predictive value of the <jats:styled-content style=\"fixed-case\">API<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=0.70, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.56\u20100.84), but had also significant predictive value on its own (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=0.65, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.52\u20100.79). Our study indicates that <jats:styled-content style=\"fixed-case\">sST<\/jats:styled-content>2 in preschool wheezers has predictive value for the development of eosinophilic airway inflammation in asthmatic children at school age.<\/jats:p>","DOI":"10.1111\/all.13193","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T07:03:05Z","timestamp":1493103785000},"page":"1811-1815","source":"Crossref","is-referenced-by-count":7,"title":["Predictive value of serum <scp>sST<\/scp>2 in preschool wheezers for development of asthma with high FeNO"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-8358","authenticated-orcid":false,"given":"M. E.","family":"Ketelaar","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Pathology and Medical Biology Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE) Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. D.","family":"van de Kant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology School for Public Health and Primary Care (CAPHRI) Maastricht University Medical Center (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. N.","family":"Dijk","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of General Practice School for Public Health and Primary Care (CAPHRI) Maastricht University Medical Center (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. S.","family":"Grotenboer","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Pathology and Medical Biology Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE) Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Nawijn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE) Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dompeling","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology School for Public Health and Primary Care (CAPHRI) Maastricht University Medical Center (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital Groningen Research Institute for Asthma and COPD (GRIAC) University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1537OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.028"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13679"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.09.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2692"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1080"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-210"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01185.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/162571"},{"key":"e_1_2_6_14_1","first-page":"CD011439","article-title":"Exhaled nitric oxide levels to guide treatment for children with asthma","volume":"9","author":"Petsky HL","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871524915666150710123415"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03774.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2013.870261"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04629.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2017.37.2.137"},{"key":"e_1_2_6_20_1","first-page":"30496","article-title":"Prognostic Value of Soluble Suppression of Tumorigenicity\u20102 in Chronic Heart Failure: a Meta\u2010Analysis","volume":"2","author":"Aimo A","year":"2016","journal-title":"JACC Heart Fail"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.03.007"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:01:18Z","timestamp":1693195278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,23]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/all.13193"],"URL":"https:\/\/doi.org\/10.1111\/all.13193","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"type":"print","value":"0105-4538"},{"type":"electronic","value":"1398-9995"}],"subject":[],"published":{"date-parts":[[2017,5,23]]}}}