{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:08:17Z","timestamp":1792080497514,"version":"4.4.0"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This\n                    <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\n                    position paper aims at providing a state\u2010of\u2010the\u2010art overview on nonallergic rhinitis (\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    ). A significant number of patients suffering from persistent rhinitis are defined as nonallergic noninfectious rhinitis (\n                    <jats:styled-content style=\"fixed-case\">NANIR<\/jats:styled-content>\n                    ) patients, often denominated in short as having\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    is defined as a symptomatic inflammation of the nasal mucosa with the presence of a minimum of two nasal symptoms such as nasal obstruction, rhinorrhea, sneezing, and\/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens. Symptoms of\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    may have a wide range of severity and be either continuously present and\/or induced by exposure to unspecific triggers, also called nasal hyperresponsiveness (\n                    <jats:styled-content style=\"fixed-case\">NHR<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">NHR<\/jats:styled-content>\n                    represents a clinical feature of both\n                    <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    patients.\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    involves different subgroups: drug\u2010induced rhinitis, (nonallergic) occupational rhinitis, hormonal rhinitis (including pregnancy rhinitis), gustatory rhinitis, senile rhinitis, and idiopathic rhinitis (\n                    <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    should be distinguished from those rhinitis patients with an allergic reaction confined to the nasal mucosa, also called \u201centopy\u201d or local allergic rhinitis (\n                    <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>\n                    ). We here provide an overview of the current consensus on phenotypes of\n                    <jats:styled-content style=\"fixed-case\">NAR<\/jats:styled-content>\n                    , recommendations for diagnosis, a treatment algorithm, and defining the unmet needs in this neglected area of research.\n                  <\/jats:p>","DOI":"10.1111\/all.13200","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T07:19:08Z","timestamp":1493968748000},"page":"1657-1665","source":"Crossref","is-referenced-by-count":277,"title":["Non\u2010allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology"],"prefix":"10.1111","volume":"72","author":[{"given":"P. W.","family":"Hellings","sequence":"first","affiliation":[{"name":"Clinical division of Otorhinolaryngology Head &amp; Neck Surgery University Hospitals Leuven Leuven Belgium"},{"name":"Laboratory of Clinical Immunology Department of Microbiology and Immunology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-5092","authenticated-orcid":false,"given":"C.","family":"Cingi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of Eskisehir Osmangazi Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Agache","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Transylvania University Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research Christine Kuhne-Center for Allergy Research and Education University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-1665","authenticated-orcid":false,"given":"C.","family":"Bachert","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bousquet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Arnaud de Villeneuve University Hospital of Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Demoly","sequence":"additional","affiliation":[{"name":"H\u00f4pital Arnaud de Villeneuve University Hospital of Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Hox","sequence":"additional","affiliation":[{"name":"Service d'ORL Cliniques Universitaires St-Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hupin","sequence":"additional","affiliation":[{"name":"Service d'ORL Cliniques Universitaires St-Luc Brussels Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) Pole de Pneumologie, ORL &amp; Dermatologie Universit\u00e9 catholique de Louvain (UCL) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kalogjera","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Sestre milosrdnice Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Manole","sequence":"additional","affiliation":[{"name":"ENT Department Faculty of Medicine University of Oradea Oradea Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-810X","authenticated-orcid":false,"given":"R.","family":"M\u00f6sges","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Informatics, and Epidemiology Medical Faculty University of K\u00f6ln Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mullol","sequence":"additional","affiliation":[{"name":"Unitat de Rinologia i Clinica de l'Olfacte, Servei d'Otorinolaringologia Hospital Cl\u00ednic Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Muluk","sequence":"additional","affiliation":[{"name":"ENT Department Faculty of Medicine Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Muraro","sequence":"additional","affiliation":[{"name":"The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region Department of Mother and Child Health University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece"},{"name":"University of Manchestter Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pawankar","sequence":"additional","affiliation":[{"name":"Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rondon","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rudenko","sequence":"additional","affiliation":[{"name":"London Allergyology and Immunology Center London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-9892","authenticated-orcid":false,"given":"S. F.","family":"Seys","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology Department of Microbiology and Immunology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Toskala","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery Temple University Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Van Gerven","sequence":"additional","affiliation":[{"name":"Clinical division of Otorhinolaryngology Head &amp; Neck Surgery University Hospitals Leuven Leuven Belgium"},{"name":"Laboratory of Clinical Immunology Department of Microbiology and Immunology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Upper Airway Research Laboratory Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Fokkens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Academic Medical Centre (AMC) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.027"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12040"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"issue":"23","key":"e_1_2_12_6_2","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"50","author":"Fokkens WJ","year":"2012","journal-title":"Rhinology"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.032"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12207"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.045"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12347"},{"key":"e_1_2_12_13_2","first-page":"7","article-title":"Gustatory rhinitis","volume":"48","author":"Jovancevic L","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.026"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3380"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino11.252"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01715.x"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.036"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22554"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01054.x"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61446-4"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.026"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2011.05.011"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1983.tb01441.x"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21583"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1358OC"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1.283"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.013"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3181a9d55b"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010223"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.4.460"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023904"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.04.011"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.04.019"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03450.x"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-015-0008-7"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.051"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23495"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12382"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.018"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-1-2"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin11.152"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01737.x"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12002"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.016"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.012"},{"key":"e_1_2_12_47_2","first-page":"735","article-title":"Rhinorrhea not responding to nasal corticosteroids","volume":"28","author":"Patel PN","year":"2007","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12255"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1202"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01961.x"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9701016"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112113"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.005"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04481.x"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199507030-00002"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402251111"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00975.x"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/039463201102400213"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1976.tb01683.x"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70267-7"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3206"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300366679"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000055714"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62352-6"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21202"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12131"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.008"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0441-9"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12095"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1997.670842.x"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802510186"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00203.x"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0638-1"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12219"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3004"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000216"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T23:59:24Z","timestamp":1693180764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/all.13200"],"URL":"https:\/\/doi.org\/10.1111\/all.13200","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727586976.793549413","asserted-by":"object"}]},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}