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To inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost\u2010effectiveness, and safety of\n                      <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>\n                      in the management of allergic rhinoconjunctivitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched nine international biomedical databases for published, in\u2010progress, and unpublished evidence. Studies were independently screened by two reviewers against predefined eligibility criteria and critically appraised using established instruments. Our primary outcomes of interest were symptom, medication, and combined symptom and medication scores. Secondary outcomes of interest included cost\u2010effectiveness and safety. Data were descriptively summarized and then quantitatively synthesized using random\u2010effects meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 5960 studies of which 160 studies satisfied our eligibility criteria. There was a substantial body of evidence demonstrating significant reductions in standardized mean differences (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      ) of symptom (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      \u22120.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.63, \u22120.42), medication (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      \u22120.37, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.49, \u22120.26), and combined symptom and medication (\n                      <jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>\n                      \u22120.49, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.69, \u22120.30) scores while on treatment that were robust to prespecified sensitivity analyses. There was in comparison a more modest body of evidence on effectiveness post\u2010discontinuation of\n                      <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>\n                      , suggesting a benefit in relation to symptom scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>\n                      is effective in improving symptom, medication, and combined symptom and medication scores in patients with allergic rhinoconjunctivitis while on treatment, and there is some evidence suggesting that these benefits are maintained in relation to symptom scores after discontinuation of therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13201","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T15:37:47Z","timestamp":1494517067000},"page":"1597-1631","source":"Crossref","is-referenced-by-count":301,"title":["Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-3258","authenticated-orcid":false,"given":"S.","family":"Dhami","sequence":"first","affiliation":[{"name":"Evidence\u2010Based Health Care Ltd Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Nurmatov","sequence":"additional","affiliation":[{"name":"Division of Population Medicine School of Medicine Cardiff University, Heath Park Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arasi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Allergy Unit University of Messina Messina Italy"},{"name":"Molecular Allergology and Immunomodulation\u2010Department of Pediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Khan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Monash University Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-4417","authenticated-orcid":false,"given":"M.","family":"Asaria","sequence":"additional","affiliation":[{"name":"Centre for Health Economics University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zaman","sequence":"additional","affiliation":[{"name":"Bradford School of Pharmacy Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Agarwal","sequence":"additional","affiliation":[{"name":"School of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Netuveli","sequence":"additional","affiliation":[{"name":"Institute for Health and Human Development University of East London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Roberts","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport Isle of Wight UK"},{"name":"NIHR Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK"},{"name":"Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"O.","family":"Pfaar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany"},{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Muraro","sequence":"additional","affiliation":[{"name":"Food Allergy Referral Centre Veneto Region Department of Women and Child Health Padua General University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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