{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:36:42Z","timestamp":1790152602473,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most published studies on anaphylaxis are retrospective or register based. Data on subsequent diagnostic workup are sparse. We aimed to characterize patients seen with suspected anaphylaxis at the emergency care setting (<jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>), after subsequent diagnostic workup at our Allergy Center (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study including patients from the <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>, Odense University Hospital, during May 2013\u2010April 2014. Possible anaphylaxis cases were daily identified based on a broad search profile including history and symptoms in patient records, diagnostic codes and pharmacological treatments. At the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, all patients were evaluated according to international guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 226 patients with suspected anaphylaxis, the diagnosis was confirmed in 124 (54.9%) after diagnostic workup; 118 of the 124 fulfilled <jats:styled-content style=\"fixed-case\">WAO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content> criteria of anaphylaxis at the <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>, while six were found among 46 patients with clinical suspicion but not fulfilling the <jats:styled-content style=\"fixed-case\">WAO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content> criteria at the <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>. The estimated incidence rate of anaphylaxis was 26 cases per 100 000 person\u2010years and the one\u2010year period prevalence was 0.04%. The most common elicitor was drugs (41.1%) followed by venom (27.4%) and food (20.6%). In 13 patients (10.5%), no elicitor could be identified. Mastocytosis was diagnosed in 7.7% of adult patients and was significantly associated with severe anaphylaxis. Atopic diseases were significantly associated only with food\u2010induced anaphylaxis. Cofactors were present in 58.1% and were significantly associated with severe anaphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A broad search profile in the <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content> and subsequent diagnostic workup is important for identification and classification of patients with anaphylaxis. Evaluation of comorbidities and cofactors is important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13207","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T14:52:56Z","timestamp":1495551176000},"page":"1944-1952","source":"Crossref","is-referenced-by-count":40,"title":["Patterns of anaphylaxis after diagnostic workup: A follow\u2010up study of 226 patients with suspected anaphylaxis"],"prefix":"10.1111","volume":"72","author":[{"given":"A. 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