{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:44:57Z","timestamp":1770777897552,"version":"3.50.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A relevant proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after successfully completing allergen immunotherapy (<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>). This prospective, controlled, noninterventional study used internationally standardized instruments to determine the clinical effects of a preseasonal, ultra\u2010short\u2010course booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> on clinical outcome parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This two\u2010arm study included patients aged \u226512 years with recurrent grass pollen\u2010induced seasonal <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> who had completed a successful course of any grass pollen <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> at least 5 years before enrolment. Overall, 56 patients received one preseasonal short\u2010course booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> using tyrosine\u2010absorbed grass pollen allergoids containing the adjuvant monophosphoryl lipid A (<jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>); 51 control patients received symptomatic medication. The combined symptom and medication score (<jats:styled-content style=\"fixed-case\">CSMS<\/jats:styled-content>) was recorded in the (peak) grass pollen season. Furthermore, concomitant (antiallergic) medication use, the patients\u2019 state of health, Mini Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ) results and safety\/tolerability of the treatment were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CSMS<\/jats:styled-content> in the peak grass pollen season was significantly lower in the booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> group (\u0394=38.4%, <jats:italic>P<\/jats:italic>&lt;.01). Moreover, significantly more patients in this group used no concomitant antiallergic medication throughout the peak grass pollen season. Twice as many patients in the booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> group as in the control group reported having a better state of health than in the preceding season. MiniRQLQ results showed significant differences favouring the booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>. The booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> was generally well tolerated, with only two patients reporting mild, grade 1 systemic adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Booster <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> using tyrosine\u2010absorbed allergoids containing the adjuvant <jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> effectively prevents re\u2010occurrence of symptoms in patients with grass pollen\u2010induced ARC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13240","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T13:48:46Z","timestamp":1499176126000},"page":"187-195","source":"Crossref","is-referenced-by-count":30,"title":["Ultra\u2010short\u2010course booster is effective in recurrent grass pollen\u2010induced allergic rhinoconjunctivitis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"O.","family":"Pfaar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany"},{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Informatics and Epidemiology (IMSIE) Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Pieper\u2010F\u00fcrst","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Informatics and Epidemiology (IMSIE) Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Astvatsatourov","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Informatics and Epidemiology (IMSIE) Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gerich","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Informatics and Epidemiology (IMSIE) Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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