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This study aimed to evaluate the association of IL<\/jats:styled-content>\u201025 with the Th2\u2010biased inflammatory profiles in CRS<\/jats:styled-content>wNP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nasal polyp (NP<\/jats:styled-content>) tissues and control uncinate process tissues were collected from 92 patients with CRS<\/jats:styled-content>wNP<\/jats:styled-content>, 20 patients with chronic rhinosinusitis without nasal polyps (CRS<\/jats:styled-content>sNP<\/jats:styled-content>), and 16 normal control subjects. IL<\/jats:styled-content>\u201025 expression was examined using immunohistochemistry and immunofluorescence staining, flow cytometry, RT<\/jats:styled-content>\u2010qPCR<\/jats:styled-content>, and ELISA<\/jats:styled-content>. The inflammatory profiles and clinical characteristics of 2 NP<\/jats:styled-content> subtypes (IL<\/jats:styled-content>\u201025high<\/jats:sup> and IL<\/jats:styled-content>\u201025low<\/jats:sup>) were evaluated, and the effects of IL<\/jats:styled-content>\u201025 on Th2 cytokine production in cultured dispersed polyp cells were examined in\u00a0vitro.<\/jats:p><\/jats:sec>Results<\/jats:title>The mRNA<\/jats:styled-content> and protein levels of IL<\/jats:styled-content>\u201025 were significantly increased in the polyp tissues compared with the control uncinate process tissues. The IL<\/jats:styled-content>\u201025high<\/jats:sup> subtype showed greater computed tomography scores, endoscopic scores, and Th2 response. Exposure to IL<\/jats:styled-content>\u201025 activated type 2 innate lymphoid cells and Th2 cells in NP<\/jats:styled-content> simultaneously which further increased Th2 cytokine production in\u00a0vitro.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Local IL<\/jats:styled-content>\u201025 plays a crucial role in promoting Th2\u2010biased inflammatory profiles in NP<\/jats:styled-content> and may serve as a promising therapeutic target in CRS<\/jats:styled-content>wNP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13267","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:30:06Z","timestamp":1501792206000},"page":"459-469","source":"Crossref","is-referenced-by-count":59,"title":["Local IL\u201025 contributes to Th2\u2010biased inflammatory profiles in nasal 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