{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:05:30Z","timestamp":1775855130683,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In early childhood, the allergen\u2010specific IgG repertoire is mainly directed to animal and vegetable food molecules and infrequently to airborne molecules. It is unknown whether this early pattern is maintained throughout childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the evolution of IgG and IgE responses to a broad panel of allergenic molecules from birth to age 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the sera collected between birth and age 10\u00a0years from participants in the German Multicentre Allergy Study, a birth cohort born in 1990. The IgE (cutoff \u22650.30 <jats:styled-content style=\"fixed-case\">ISU<\/jats:styled-content>) and IgG (cutoff \u22650.10 <jats:styled-content style=\"fixed-case\">ISU<\/jats:styled-content>) responses to 35 genuine allergenic molecules were measured with a multiplex microarray approach (Immuno<jats:styled-content style=\"fixed-case\">CAP ISAC<\/jats:styled-content>\u2122).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgE responses were mostly directed against a restricted group of airborne molecules, with a sequence and prevalence hierarchy (Phl p 1&gt; Bet v 1&gt; Fel d 1&gt; Phl p 5&gt; Der p 2&gt; Der p 1) largely maintained over time. Conversely, the IgG repertoire was much broader, starting with animal foodborne, then spreading to vegetable foodborne and finally to airborne molecules. A strong and persistent IgG response to a given airborne molecule almost invariably preceded or accompanied an IgE response to that molecule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The evolution of IgG and IgE responses throughout childhood differs widely at population level. IgG responses are mostly directed to animal food allergens, while IgE responses are dominated by airborne allergens. However, a strong IgG response almost invariably precedes or accompanies the appearance of IgE to the same molecule in specifically sensitized subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13269","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:02:45Z","timestamp":1502236965000},"page":"421-430","source":"Crossref","is-referenced-by-count":61,"title":["Evolution of the IgE and IgG repertoire to a comprehensive array of allergen molecules in the first decade of life"],"prefix":"10.1111","volume":"73","author":[{"given":"X.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Department of Pediatrics Shengzhou People's Hospital Shengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Tsilochristou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hofmaier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cappella","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine S. Andrea University Hospital Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010P.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Hedwig St. Josefs Hospital Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zepp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine University Medicine Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Heinrich\u2010Heine\u2010University D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"D'Amelio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine S. Andrea University Hospital Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Keil","sequence":"additional","affiliation":[{"name":"Institute for Social Medicine, Epidemiology and Health Economics Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Institute of Clinical Epidemiology and Biometry University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pneumology &amp; Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-3776","authenticated-orcid":false,"given":"P. 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