{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:03:18Z","timestamp":1788526998473,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our genomewide association study documented an association between cold medicine\u2010related Stevens\u2010Johnson syndrome\/toxic epidermal necrolysis (CM\u2010SJS\/TEN) and Ikaros Family Zinc Finger 1 (<jats:italic>IKZF1<\/jats:italic>). Few studies examined biological and pathological functions of <jats:italic>IKZF1<\/jats:italic> in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human skin and conjunctival tissues were obtained for immunohistological studies. Primary human conjunctival epithelial cells (PHCjECs) and adult human epidermal keratinocytes (HEKa) also used for gene expression analysis. We also generated K5\u2010Ikzf1\u2010EGFP transgenic mice (Ikzf1 Tg) by introducing the Ik1 isoform into cells expressing keratin 5, which is expressed in epithelial tissues such as the epidermis and conjunctiva, and then examined them histologically and investigated gene expression of the epidermis. Moreover, Ikzf1 Tg were induced allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that human epidermis and conjunctival epithelium expressed IKZF1, and in PHCjECs and HEKa, the expression of IKZF1 mRNA was upregulated by stimulation with polyI:C, a TLR3 ligand. In Ikzf1 Tg, we observed dermatitis and mucosal inflammation including the ocular surface. In contact dermatitis model, inflammatory infiltrates in the skin of Ikzf1 Tg were significantly increased compared with wild type. Microarray analysis showed that Lcn2, Adh7, Epgn, Ifi202b, Cdo1, Gpr37, Duoxa1, Tnfrsf4, and Enpp5 genes were significantly upregulated in the epidermis of Ikzf1 Tg compared with wild type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings support the hypothesis that Ikaros might participate in mucocutaneous inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13308","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T15:32:39Z","timestamp":1505489559000},"page":"395-404","source":"Crossref","is-referenced-by-count":24,"title":["Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1\u2010keratin 5\u2013specific transgenic mice"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-5024","authenticated-orcid":false,"given":"M.","family":"Ueta","sequence":"first","affiliation":[{"name":"Department of Frontier Medical Science and Technology for Ophthalmology Kyoto 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hitomi","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tamagawa\u2010Mineoka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Kyoto Prefectural University of Medicine Kyoto 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