{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:59:08Z","timestamp":1776329948763,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF 108"],"award-info":[{"award-number":["DNRF 108"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies have suggested that Bacillus Calmette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) vaccination may reduce the risk of allergic diseases, including atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Danish Calmette Study was conducted 2012\u20102015. Within 7 days of birth new\u2010borns were randomised 1:1 to <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> or no <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>. Exclusion criteria were gestational age &lt;32 weeks, birth weight &lt;1000 g, known immunodeficiency or no Danish\u2010speaking parent. Data were collected through telephone interviews and clinical examinations until 13 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical atopic dermatitis was diagnosed in 466\/2,052 (22.7%) children in the <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> group and 495\/1,952 (25.4%) children in the control group (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> = 0.90 [95% confidence intervals 0.80\u20101.00]). The effect of neonatal <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccination differed significantly between children with atopic predisposition (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.84 (0.74\u20100.95)) and children without atopic predisposition (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.09 [0.88\u20101.37]) (test of no interaction, <jats:italic>P<\/jats:italic> = .04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among children with atopic predisposition, the number\u2010needed\u2010to\u2010treat with <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> to prevent one case of atopic dermatitis was 21 (12\u201076).<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13314","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T08:52:45Z","timestamp":1505897565000},"page":"498-504","source":"Crossref","is-referenced-by-count":46,"title":["Neonatal <scp>BCG<\/scp> vaccination and atopic dermatitis before 13 months of age: A randomized clinical trial"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-1260","authenticated-orcid":false,"given":"L. M.","family":"Th\u00f8stesen","sequence":"first","affiliation":[{"name":"Paediatric Department Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Paediatric Department Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"Pihl","sequence":"additional","affiliation":[{"name":"Paediatric Department Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Birk","sequence":"additional","affiliation":[{"name":"Paediatric Department Hvidovre Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. N.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Paediatric Department Hvidovre Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Aaby","sequence":"additional","affiliation":[{"name":"Bandim Health Project SSI Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K. G.","family":"Jensen","sequence":"additional","affiliation":[{"name":"CVIVA Bandim Health Project SSI &amp; Section of Biostatistics, University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-153X","authenticated-orcid":false,"given":"L. G.","family":"Stensballe","sequence":"additional","affiliation":[{"name":"The Child and Adolescent Clinic Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Paediatric Department Hvidovre Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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