{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:34Z","timestamp":1791896374830,"version":"4.3.4"},"reference-count":223,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011824","name":"EAACI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011824","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BM4SIT project","award":["601763"],"award-info":[{"award-number":["601763"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side\u2010effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease\u2010modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on AIT for AR and is part of the EAACI presidential project \u201cEAACI Guidelines on Allergen Immunotherapy.\u201d It aims to provide evidence\u2010based clinical recommendations and has been informed by a formal systematic review and meta\u2010analysis. Its generation has followed the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included involvement of the full range of stakeholders. In general, broad evidence for the clinical efficacy of AIT for AR exists but a product\u2010specific evaluation of evidence is recommended. In general, SCIT and SLIT are recommended for both seasonal and perennial AR for its short\u2010term benefit. The strongest evidence for long\u2010term benefit is documented for grass AIT (especially for the grass tablets) where long\u2010term benefit is seen. To achieve long\u2010term efficacy, it is recommended that a minimum of 3\u00a0years of therapy is used. Many gaps in the evidence base exist, particularly around long\u2010term benefit and use in children.<\/jats:p>","DOI":"10.1111\/all.13317","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T03:02:45Z","timestamp":1506135765000},"page":"765-798","source":"Crossref","is-referenced-by-count":690,"title":["EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1248","authenticated-orcid":false,"given":"G.","family":"Roberts","sequence":"first","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport, Isle of Wight UK"},{"name":"NIHR Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK"},{"name":"Clinical and Experimental Sciences and Human Development in Health Academic Units Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"O.","family":"Pfaar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany"},{"name":"Center for Rhinology and Allergology Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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