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There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>) through the oral (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>), sublingual (<jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>), or epicutaneous (<jats:styled-content style=\"fixed-case\">EPIT<\/jats:styled-content>) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (<jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>) Task Force on Allergen Immunotherapy for IgE\u2010mediated Food Allergy, aims to provide evidence\u2010based recommendations for active treatment of IgE\u2010mediated food allergy with <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>. Immunotherapy relies on the delivery of gradually increasing doses of specific allergen to increase the threshold of reaction while on therapy (also known as desensitization) and ultimately to achieve post\u2010discontinuation effectiveness (also known as tolerance or sustained unresponsiveness). Oral <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> has most frequently been assessed: here, the allergen is either immediately swallowed (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>) or held under the tongue for a period of time (<jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>). Overall, trials have found substantial benefit for patients undergoing either <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> with respect to efficacy during treatment, particularly for cow's milk, hen's egg, and peanut allergies. A benefit post\u2010discontinuation is also suggested, but not confirmed. Adverse events during <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> have been frequently reported, but few subjects discontinue <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> as a result of these. Taking into account the current evidence, <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> should only be performed in research centers or in clinical centers with an extensive experience in <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>. Patients and their families should be provided with information about the use of <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> for IgE\u2010mediated food allergy to allow them to make an informed decision about the therapy.<\/jats:p>","DOI":"10.1111\/all.13319","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:45:55Z","timestamp":1506613555000},"page":"799-815","source":"Crossref","is-referenced-by-count":508,"title":["<scp>EAACI<\/scp> Guidelines on allergen immunotherapy: IgE\u2010mediated food allergy"],"prefix":"10.1111","volume":"73","author":[{"given":"G. 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