{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:25:20Z","timestamp":1772627120409,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","award":["FARM8YRYZC"],"award-info":[{"award-number":["FARM8YRYZC"]}],"id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008245","name":"Center for Neuroscience Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Italian severe\/uncontrolled asthma (<jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content>) web\u2010based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> awareness, identifying specific phenotypes and promoting optimal care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011\u20102014) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 53.8\u00a0years. <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis\/symptoms (&gt;40\u00a0years); the mean age for asthma symptoms onset was 30.2\u00a0years and for asthma diagnosis 34.4\u00a0years. 97.1% used <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> (dose 2000 <jats:styled-content style=\"fixed-case\">BDP<\/jats:styled-content>), 93.6% <jats:styled-content style=\"fixed-case\">LABA<\/jats:styled-content> in association with <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>, 53.3% <jats:styled-content style=\"fixed-case\">LTRA<\/jats:styled-content>s, 64.1% anti\u2010IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>% pred of 75.1%, median values of 300\/mm<jats:sup>3<\/jats:sup> of blood eosinophil count, 323\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L of serum total IgE, and 24\u00a0ppb of <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> patients had exacerbations in the last 12\u00a0months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.46, 1.11\u20105.41), psychic disorders (2.87, 0.89\u20109.30\u2014borderline), nasal polyps (1.86, 0.88\u20103.89\u2014borderline), partial\/poor asthma treatment adherence (2.54, 0.97\u20106.67\u2014borderline), and anti\u2010IgE use in a protective way (0.26, 0.12\u20100.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An international effort in the implementation of <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> patients\u2019 registries could help to better understand the clinical features and to manage severe asthma, representing a non\u2010negligible socioeconomic burden for health services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13342","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T16:06:37Z","timestamp":1509033997000},"page":"683-695","source":"Crossref","is-referenced-by-count":56,"title":["RItA: The Italian severe\/uncontrolled asthma registry"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-8544","authenticated-orcid":false,"given":"S.","family":"Maio","sequence":"first","affiliation":[{"name":"Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Baldacci","sequence":"additional","affiliation":[{"name":"Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bresciani","sequence":"additional","affiliation":[{"name":"Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Simoni","sequence":"additional","affiliation":[{"name":"Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Latorre","sequence":"additional","affiliation":[{"name":"Cardio\u2010Thoracic and Vascular Department University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Murgia","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Spinozzi","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Braschi","sequence":"additional","affiliation":[{"name":"Allergy Unit Internal Medicine Department AOU Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Antonicelli","sequence":"additional","affiliation":[{"name":"Allergy Unit Internal Medicine Department AOU Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Brunetto","sequence":"additional","affiliation":[{"name":"Immunology Department Italian National Health Institute (ISS) Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Iacovacci","sequence":"additional","affiliation":[{"name":"Immunology Department Italian National Health Institute (ISS) Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Roazzi","sequence":"additional","affiliation":[{"name":"Immunology Department Italian National Health Institute (ISS) Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pini","sequence":"additional","affiliation":[{"name":"Immunology Department Italian National Health Institute (ISS) Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pata","sequence":"additional","affiliation":[{"name":"Roche S.p.A. 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