{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:47:41Z","timestamp":1778665661700,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008493","name":"V\u00e4in\u00f6 ja Laina Kiven S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Five studies carried out after bronchiolitis at less than 24\u00a0months of age, with a follow\u2010up of more than 10\u00a0years, reported that atopic dermatitis, family asthma, early\u2010life exposure to tobacco smoke and rhinovirus aetiology were early\u2010life risk factors for later asthma. This study evaluated the long\u2010term outcome at 11\u201013\u00a0years of age of children who were hospitalized for bronchiolitis in early infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We previously prospectively followed 166 children hospitalized for bronchiolitis at less than 6\u00a0months of age until 5\u20107\u00a0years of age. The current study included a structured questionnaire, parental interviews, clinical examinations and bronchodilation test of 138 of those children at 11\u201013\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Respiratory syncytial virus caused 66% of the bronchiolitis cases, and nearly half of the patients were exposed to tobacco smoke in early life. Doctor\u2010diagnosed asthma was present in 13% of the former bronchiolitis patients at 11\u201013\u00a0years of age. Maternal asthma was the only independently significant risk factor in early life (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.45, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.07\u201011.74), as was allergic rhinitis at 5\u20107\u00a0years of age (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.35\u201012.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After bronchiolitis at less than 6\u00a0months of age, the risk of doctor\u2010diagnosed asthma at 11\u201013\u00a0years was about twice that of the general Finnish population. Maternal asthma was the only independently significant early\u2010life risk factor for current asthma at 11\u201013\u00a0years of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13347","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T07:32:39Z","timestamp":1509780759000},"page":"916-922","source":"Crossref","is-referenced-by-count":39,"title":["Risk factors for asthma after infant bronchiolitis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-3652","authenticated-orcid":false,"given":"S.","family":"T\u00f6rm\u00e4nen","sequence":"first","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lauhkonen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Riikonen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Koponen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huhtala","sequence":"additional","affiliation":[{"name":"School of Health Sciences Tampere University Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Helminen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere 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