{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:42:54Z","timestamp":1788306174184,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Elevated levels of C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria (CSU). Here, we retrospectively analyzed data from 1253\n CSU<\/jats:styled-content>\n patients from 2 centers to answer the following questions: (i) What is the prevalence of elevated levels of\n CRP<\/jats:styled-content>\n in\n CSU<\/jats:styled-content>\n ? (ii) Why do\n CSU<\/jats:styled-content>\n patients show elevated levels of\n CRP<\/jats:styled-content>\n ? (iii) Are elevated\n CRP<\/jats:styled-content>\n levels relevant?\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Serum levels of\n CRP<\/jats:styled-content>\n were measured by the nephelometric method. We collected information regarding various laboratory tests including\n ESR<\/jats:styled-content>\n ,\n CBC<\/jats:styled-content>\n with differential, D\u2010dimer, fibrinogen, C3, C4,\n IL<\/jats:styled-content>\n \u20106, etc. For most patients, we also collected data on age, gender, duration of\n CSU<\/jats:styled-content>\n , presence of angioedema, activity (\n UAS<\/jats:styled-content>\n at the time of blood sampling and for 7 days), quality of life (\n CU<\/jats:styled-content>\n \u2010Q2oL and\/or\n DLQI<\/jats:styled-content>\n ), comorbidities and possible causes of\n CSU<\/jats:styled-content>\n , and autologous serum skin test (\n ASST<\/jats:styled-content>\n ) response. The efficacy of second\u2010generation antihistamines was evaluated on the day of blood collecting.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One\u2010third of\n CSU<\/jats:styled-content>\n patients had elevated levels of\n CRP<\/jats:styled-content>\n . Higher levels of\n CRP<\/jats:styled-content>\n were associated with\n ASST<\/jats:styled-content>\n positivity (\n P<\/jats:italic>\n = .009) and arterial hypertension (\n P<\/jats:italic>\n = .005), but not with other possible causes or comorbidities of\n CSU<\/jats:styled-content>\n . C\u2010reactive protein correlated with urticaria activity (\n P<\/jats:italic>\n < .001), quality of life impairment (\n P<\/jats:italic>\n = .026), and inflammatory and coagulation markers (\n P<\/jats:italic>\n < .001). C\u2010reactive protein levels were significantly higher in nonresponders to antihistamines as compared to responders (\n P<\/jats:italic>\n < .001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Elevated levels of\n CRP<\/jats:styled-content>\n are common and relevant in\n CSU<\/jats:styled-content>\n patients. The assessment of\n CRP<\/jats:styled-content>\n levels may help to optimize the management of patients with\n CSU<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13352","type":"journal-article","created":{"date-parts":[[2017,11,12]],"date-time":"2017-11-12T07:16:39Z","timestamp":1510470999000},"page":"940-948","source":"Crossref","is-referenced-by-count":103,"title":["C\u2010reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria"],"prefix":"10.1111","volume":"73","author":[{"given":"P.","family":"Kolkhir","sequence":"first","affiliation":[{"name":"Division of Immune\u2010mediated skin diseases Department of Dermatology and Venereology I.M. Sechenov First Moscow State Medical University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-385X","authenticated-orcid":false,"given":"S.","family":"Altrichter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hawro","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12313"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12870"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2013.3.2.100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/650913"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Elevated C\u2010reactive protein (CRP) levels in patients with recurrent urticaria and\/or angioedema","volume":"2","author":"Lin R","year":"2001","journal-title":"Int J Asthma Allergy Immunol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181db6ed5"},{"key":"e_1_2_8_8_1","first-page":"168","article-title":"[Association between C reactive protein and clinical characteristics in patients with chronic spontaneous 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