{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T21:40:49Z","timestamp":1775598049596,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    IgE antibodies (Ab) specific to galactose\u2010\u03b1\u20101,3\u2010galactose (alpha\u2010gal) are responsible for a delayed form of anaphylaxis that occurs 3\u20106\u00a0hours after red meat ingestion. In a unique prospective study of seventy participants referred with a diagnosis of idiopathic anaphylaxis (\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    ), six (9%) were found to have IgE to alpha\u2010gal. Upon institution of a diet free of red meat, all patients had no further episodes of anaphylaxis. Two of these individuals had indolent systemic mastocytosis (\n                    <jats:styled-content style=\"fixed-case\">ISM<\/jats:styled-content>\n                    ). Those with\n                    <jats:styled-content style=\"fixed-case\">ISM<\/jats:styled-content>\n                    had more severe clinical reactions but lower specific IgE to alpha\u2010gal and higher serum tryptase levels, reflective of the mast cell burden. The identification of alpha\u2010gal syndrome in patients with\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    supports the need for routine screening for this sensitivity as a cause of anaphylaxis, where reactions to alpha\u2010gal are delayed and thus may be overlooked.\n                  <\/jats:p>","DOI":"10.1111\/all.13366","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T18:26:34Z","timestamp":1511288794000},"page":"1131-1134","source":"Crossref","is-referenced-by-count":61,"title":["Identification of alpha\u2010gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-5366","authenticated-orcid":false,"given":"M. C.","family":"Carter","sequence":"first","affiliation":[{"name":"Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. N.","family":"Ruiz\u2010Esteves","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Workman","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pediatrics University of Tennessee College of Medicine Germantown TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A. E.","family":"Platts\u2010Mills","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology University of Virginia Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. D.","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.11.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1016\/S0021-9258(17)42779-7","article-title":"Occurrence of alpha\u2010D\u2010galactosyl residues in the thyroglobulins from several species. 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