{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:40:26Z","timestamp":1777941626739,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sophia Children's Hospital Fund","award":["S698"],"award-info":[{"award-number":["S698"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the critical role of soluble IgE in the pathology of IgE\u2010mediated allergic disease, little is known about abnormalities in the memory B cells and plasma cells that produce IgE in allergic patients. We here applied a flow cytometric approach to cross\u2010sectionally study blood IgE+ memory B cells and plasmablasts in 149 children with atopic dermatitis, food allergy, and\/or asthma and correlated these to helper T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>27\u2010 and IgE+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>27+ memory B cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells. IgE+ plasmablast numbers correlated positively with Th2 cell numbers. These findings open new possibilities for diagnosis and monitoring of treatment in patients with allergic diseases.<\/jats:p>","DOI":"10.1111\/all.13421","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T14:03:01Z","timestamp":1517320981000},"page":"1331-1336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["IgE\u2010expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-8977","authenticated-orcid":false,"given":"J. J.","family":"Heeringa","sequence":"first","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rijvers","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Arends","sequence":"additional","affiliation":[{"name":"Department of Allergy Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Haga Teaching Hospital Juliana Children's Hospital The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G.","family":"Pasmans","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J. M.","family":"van Dongen","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Immunology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Respiratory Medicine Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-1919","authenticated-orcid":false,"given":"M. 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