{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:36:53Z","timestamp":1790152613209,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study population consisted of children with a double\u2010blind, placebo\u2010controlled food challenge (\n DBPCFC<\/jats:styled-content>\n )\u2013confirmed food allergy to milk, egg, peanut, cashew nut, and\/or hazelnut. The data were analyzed using multiple linear regression analysis. Missing values were imputed using multiple imputation techniques. Two scoring systems were used to determine the severity of the reactions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 734 children were included. Independent predictors for the severity of the\n DBPCFC<\/jats:styled-content>\n reaction were age (B = 0.04,\n P<\/jats:italic>\n = .001), skin prick test ratio (B = 0.30,\n P<\/jats:italic>\n < .001), eliciting dose (B = \u22120.09,\n P<\/jats:italic>\n < .001), level of specific immunoglobulin E (B = 0.15,\n P<\/jats:italic>\n < .001), reaction time during the\n DBPCFC<\/jats:styled-content>\n (B = \u22120.01,\n P<\/jats:italic>\n = .004), and severity of accidental reaction (B = 0.08,\n P<\/jats:italic>\n = .015). The total explained variance of this model was 23.5%, and the eliciting dose only contributed 4.4% to the model. Independent predictors for more severe accidental reactions with an explained variance of 7.3% were age (B = 0.03,\n P<\/jats:italic>\n = .014), milk as causative food (B = 0.77,\n P<\/jats:italic>\n < .001), cashew as causative food (B = 0.54,\n P<\/jats:italic>\n < .001), history of atopic dermatitis (B = \u22120.47,\n P<\/jats:italic>\n = .006), and severity of\n DBPCFC<\/jats:styled-content>\n reaction (B = 0.12,\n P<\/jats:italic>\n = .003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The severity of\n DBPCFC<\/jats:styled-content>\n s and accidental reactions to food remains largely unpredictable. Clinicians should not use the eliciting dose obtained from a graded food challenge for the purposes of making risk\u2010related management decisions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13423","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T03:12:55Z","timestamp":1517281975000},"page":"1532-1540","source":"Crossref","is-referenced-by-count":77,"title":["Prediction of the severity of allergic reactions to foods"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-3143","authenticated-orcid":false,"given":"M. E.","family":"Pettersson","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergy University Medical Center Groningen, University of Groningen Groningen The Netherlands"},{"name":"GRIAC Research Institute University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergy University Medical Center Groningen, University of Groningen Groningen The Netherlands"},{"name":"GRIAC Research Institute University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M. J.","family":"Flokstra\u2010de Blok","sequence":"additional","affiliation":[{"name":"GRIAC Research Institute University Medical Center Groningen, University of Groningen Groningen The Netherlands"},{"name":"Department of General Practice University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Kollen","sequence":"additional","affiliation":[{"name":"Department of General Practice University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-0296","authenticated-orcid":false,"given":"A. E. J.","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergy University Medical Center Groningen, University of Groningen Groningen The Netherlands"},{"name":"GRIAC Research Institute University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S3.1601"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12924"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02838.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.063"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.11.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00602.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70133-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01200.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02312.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104941"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12107"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.02.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.047"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01063.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.035"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.039"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00466.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01430.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.1886.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.053"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.050"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1304"},{"key":"e_1_2_9_28_1","article-title":"Quantitative assessment of the safety benefits associated with increasing clinical peanut thresholds through immunotherapy","author":"Baumert JL","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02795.x"},{"key":"e_1_2_9_30_1","first-page":"24","article-title":"Predictive values for food challenge\u2010induced severe reactions: development of a simple food challenge score","volume":"14","author":"Cianferoni A","year":"2012","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12687"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.01.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02628.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12997"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:01:49Z","timestamp":1694800909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,4]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/all.13423"],"URL":"https:\/\/doi.org\/10.1111\/all.13423","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,4]]}}}