{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:38:18Z","timestamp":1773070698819,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with mastocytosis are at increased risk of anaphylaxis. The use of nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) is often discouraged because of this reason. However, the actual prevalence and severity of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010related hypersensitivity among patients with mastocytosis is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, placebo\u2010controlled acetylsalicylic acid (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>) challenge up to a cumulative dose of 520\u00a0mg was performed among adult patients with mastocytosis. In addition, a retrospective search of the entire outpatient cohort was performed to obtain \u201creal\u2010life\u201d data on <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients underwent an <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> challenge. Seventy percent had indolent systemic mastocytosis, 18% had mastocytosis in the skin, and 12% had advanced mastocytosis. The <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> challenge was positive in 1 patient who developed urticaria. The additional retrospective chart review revealed that 8 of 191 patients had a history of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010related hypersensitivity reaction(s), of whom 3 reported severe systemic reactions. All 8 patients had already experienced <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010related hypersensitivity reactions before mastocytosis was diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The frequency of <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> hypersensitivity was 2% in a prospective challenge study and 4.1% in a retrospective chart review of 191 patients with mastocytosis. <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s can be administered safely to most patients with mastocytosis. Extra caution should be taken in patients with a history of hypersensitivity reactions to other drugs, or traditional risk factors for <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13445","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T06:33:11Z","timestamp":1521786791000},"page":"2055-2062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Low frequency of acetyl salicylic acid hypersensitivity in mastocytosis: The results of a double\u2010blind, placebo\u2010controlled challenge study"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-8387","authenticated-orcid":false,"given":"M. A. 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