{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:19Z","timestamp":1787244319437,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Meda, The Fondation Partenariale FMC VIA LR"},{"name":"EU (R\u00e9gion Languedoc Roussillon)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the\n                      <jats:italic>Allergy Diary<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We undertook a 1\u2010year prospective observational study in which 4 210 users and 32\u00a0585\u00a0days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels &lt;20\/100 were categorized as \u201cLow\u201d burden and VAS levels \u226550\/100 as \u201cHigh\u201d burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis\u2010driven patterns were defined based on \u201cLow\u201d and \u201cHigh\u201d VAS levels. There were &lt;0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High\u2014Asthma Low pattern. There were 1.7% days with a Rhinitis High\u2014Asthma High\u2014Conjunctivitis Low pattern. A novel Rhinitis High\u2014Asthma High\u2014Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a novel approach examining daily symptoms with mobile technology, we found considerable intra\u2010individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13448","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T03:14:54Z","timestamp":1521774894000},"page":"1622-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the\n                    <scp>MASK<\/scp>\n                    study"],"prefix":"10.1111","volume":"73","author":[{"given":"J.","family":"Bousquet","sequence":"first","affiliation":[{"name":"MACVIA\u2010France Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site Montpellier France"},{"name":"INSERM U 1168 VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"UMR\u2010S 1168 Universit\u00e9 Versailles St\u2010Quentin\u2010en\u2010Yvelines Montigny le Bretonneux France"},{"name":"Euforea Brussels Belgium"},{"name":"Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-8317","authenticated-orcid":false,"given":"P.","family":"Devillier","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie Respiratoire UPRES EA220 P\u00f4le des Maladies Respiratoires H\u00f4pital Foch Suresnes Universit\u00e9 Versailles Saint\u2010Quentin Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Anto","sequence":"additional","affiliation":[{"name":"ISGloBAL Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"IMIM (Hospital del Mar Research Institute) Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bewick","sequence":"additional","affiliation":[{"name":"iQ4U Consultants Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Haahtela","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arnavielhe","sequence":"additional","affiliation":[{"name":"Kyomed Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bedbrook","sequence":"additional","affiliation":[{"name":"MACVIA\u2010France Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Murray","sequence":"additional","affiliation":[{"name":"MedScript Ltd Dundalk Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van Eerd","sequence":"additional","affiliation":[{"name":"Peercode DV Gerdermalsen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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