{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:24:56Z","timestamp":1791235496285,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["OMRP3B0011"],"award-info":[{"award-number":["OMRP3B0011"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Exposure to environmental pollutants promotes Th2 cell responses. Aryl hydrocarbon receptor (AhR) activation aggravates allergic responses. Epithelium\u2010derived thymic stromal lymphopoietin (\n TSLP<\/jats:styled-content>\n ), interleukin (\n IL<\/jats:styled-content>\n )\u201025, and\n IL<\/jats:styled-content>\n \u201033 are implicated in the dysregulation of Th2 immune responses in severe allergic asthma.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Bronchial biopsies of 28 allergic severe asthma and 6 mild asthma subjects from highly polluted areas were analyzed for AhR nuclear translocation (\n NT<\/jats:styled-content>\n ), cytokine expression, and gene activation. Cultured primary epithelial cells were stimulated with diesel exhausted particles (\n DEP<\/jats:styled-content>\n ) to determine AhR\u2010mediated\n IL<\/jats:styled-content>\n \u201033, Il\u201025, and\n TSLP<\/jats:styled-content>\n synthesis and release.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Primary bronchial epithelial cells exposed to\n DEP<\/jats:styled-content>\n showed upregulation of\n IL<\/jats:styled-content>\n \u201033,\n IL<\/jats:styled-content>\n \u201025, and\n TSLP<\/jats:styled-content>\n . These effects were abolished by knockdown of AhR by si\n RNA<\/jats:styled-content>\n . Increased AhR\/\n ARNT<\/jats:styled-content>\n binding to promoters of\n IL<\/jats:styled-content>\n \u201033,\n IL<\/jats:styled-content>\n \u201025, and\n TSLP<\/jats:styled-content>\n was found using chromatin immunoprecipitation (Ch\n IP<\/jats:styled-content>\n ) assay. Allergic severe asthma with high AhR\n NT<\/jats:styled-content>\n had higher bronchial gene and protein expression of\n IL<\/jats:styled-content>\n \u201033,\n IL<\/jats:styled-content>\n \u201025, and\n TSLP<\/jats:styled-content>\n . These patients derived clinical benefit from anti\u2010IgE treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Aryl hydrocarbon receptor activation by\n DEP<\/jats:styled-content>\n mediates upregulation of\n IL<\/jats:styled-content>\n \u201033,\n IL<\/jats:styled-content>\n \u201025, and\n TSLP<\/jats:styled-content>\n with Th2 activation, potentially linking environmental pollution and allergic severe asthma.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13462","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T16:00:21Z","timestamp":1524153621000},"page":"2192-2204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium\u2010derived cytokines expression in severe allergic asthma"],"prefix":"10.1111","volume":"73","author":[{"given":"C.\u2010M.","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Medicine Taipei Medical University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Department of Thoracic Medicine Chang Gung Memorial Hospital Chang Gung Medical Foundation Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Taipei Medical University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010R.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Chang Gung Memorial Hospital Chang Gung Medical Foundation Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Chang Gung Memorial Hospital Chang Gung Medical Foundation Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010W.","family":"Chao","sequence":"additional","affiliation":[{"name":"Center of Nanotechnology Chung Yuan Christian University Zhongli District, Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. F.","family":"Chung","sequence":"additional","affiliation":[{"name":"Airway Disease Section National Heart and Lung Institute Imperial College London London UK"},{"name":"NIHR Respiratory Biomedical Research Unit Royal Brompton NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-2440","authenticated-orcid":false,"given":"H.\u2010P.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Medicine Taipei Medical University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.03.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.08.009"},{"key":"e_1_2_8_6_1","first-page":"14","article-title":"Link between environmental air pollution and allergic asthma: east meets West","volume":"7","author":"Zhang Q","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.048"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00115.2010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0305-223"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800319"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4639-00248"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0057OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq028"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0132OC"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812110"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-99"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00499-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.09.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i4.10"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.02.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2617"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.146"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06880"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.09.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13166"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-011-0075-8"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13462","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:43:28Z","timestamp":1694731408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/all.13462"],"URL":"https:\/\/doi.org\/10.1111\/all.13462","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}