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The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes in the transcriptional and epigenetic regulation in rhinovirus\u2010associated atopic or nonatopic asthma, we analyzed a cohort of 5\u2010year\u2010old children (n\u00a0=\u00a045) according to the virus etiology of the first severe wheezing episode at the mean age of 13\u00a0months and to 5\u2010year asthma outcome. The development of atopic asthma in children with early rhinovirus\u2010induced wheezing was associated with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation changes at several genomic sites in chromosomal regions previously linked to asthma. The strongest changes in atopic asthma were detected in the promoter region of <jats:italic><jats:styled-content style=\"fixed-case\">SMAD<\/jats:styled-content>3<\/jats:italic> gene at chr 15q22.33 and introns of <jats:italic><jats:styled-content style=\"fixed-case\">DDO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">METTL<\/jats:styled-content>24<\/jats:italic> genes at 6q21. These changes were validated to be present also at the average age of 8\u00a0years.<\/jats:p>","DOI":"10.1111\/all.13473","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T19:08:52Z","timestamp":1525547332000},"page":"1735-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Atopic asthma after rhinovirus\u2010induced wheezing is associated with <scp>DNA<\/scp> methylation change in the <i><scp>SMAD<\/scp>3<\/i> gene promoter"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-5918","authenticated-orcid":false,"given":"R. 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