{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:54:59Z","timestamp":1790506499979,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T00:00:00Z","timestamp":1543104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n High\u2010molecular\u2010weight (\n HMW<\/jats:styled-content>\n ) proteins and low\u2010molecular\u2010weight (\n LMW<\/jats:styled-content>\n ) chemicals can cause occupational asthma (\n OA<\/jats:styled-content>\n ) although few studies have thoroughly compared the clinical, physiological, and inflammatory patterns associated with these different types of agents. The aim of this study was to determine whether\n OA<\/jats:styled-content>\n induced by\n HMW<\/jats:styled-content>\n and\n LMW<\/jats:styled-content>\n agents shows distinct phenotypic profiles.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Clinical and functional characteristics, and markers of airway inflammation were analyzed in an international, multicenter, retrospective cohort of subjects with\n OA<\/jats:styled-content>\n ascertained by a positive inhalation challenge response to\n HMW<\/jats:styled-content>\n (n\u00a0=\u00a0544) and\n LMW<\/jats:styled-content>\n (n\u00a0=\u00a0635) agents.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Multivariate logistic regression analysis showed significant associations between\n OA<\/jats:styled-content>\n caused by\n HMW<\/jats:styled-content>\n agents and work\u2010related rhinitis (\n OR<\/jats:styled-content>\n [95%\n CI<\/jats:styled-content>\n ]: 4.79 [3.28\u20107.12]), conjunctivitis (2.13 [1.52\u20102.98]), atopy (1.49 [1.09\u20102.05]), and early asthmatic reactions (2.86 [1.98\u20104.16]). By contrast,\n OA<\/jats:styled-content>\n due to\n LMW<\/jats:styled-content>\n agents was associated with chest tightness at work (2.22 [1.59\u20103.03]), daily sputum (1.69 [1.19\u20102.38]), and late asthmatic reactions (1.52 [1.09\u20102.08]). Furthermore,\n OA<\/jats:styled-content>\n caused by\n HMW<\/jats:styled-content>\n agents showed a higher risk of airflow limitation (1.76 [1.07\u20102.91]), whereas\n OA<\/jats:styled-content>\n due to\n LMW<\/jats:styled-content>\n agents exhibited a higher risk of severe exacerbations (1.32 [1.01\u20101.69]). There were no differences between the two types of agents in the baseline sputum inflammatory profiles, but\n OA<\/jats:styled-content>\n caused by\n HMW<\/jats:styled-content>\n agents showed higher baseline blood eosinophilia and a greater postchallenge increase in fractional nitric oxide.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This large cohort study describes distinct phenotypic profiles in\n OA<\/jats:styled-content>\n caused by\n HMW<\/jats:styled-content>\n and\n LMW<\/jats:styled-content>\n agents. There is a need to further explore differences in underlying pathophysiological pathways and outcome after environmental interventions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13542","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T02:54:43Z","timestamp":1530240883000},"page":"261-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Are high\u2010 and low\u2010molecular\u2010weight sensitizing agents associated with different clinical phenotypes of occupational asthma?"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-3310","authenticated-orcid":false,"given":"Olivier","family":"Vandenplas","sequence":"first","affiliation":[{"name":"Department of Chest Medicine Centre Hospitalier Universitaire UCL Namur Universit\u00e9 Catholique de Louvain Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Godet","sequence":"additional","affiliation":[{"name":"P\u00f4le de Sant\u00e9 Publique Strasbourg University Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hurdubaea","sequence":"additional","affiliation":[{"name":"Division of Asthma and Allergy Department of Chest Diseases University Hospital of Strasbourg and F\u00e9d\u00e9ration de M\u00e9decine translationnelle Strasbourg University Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Rifflart","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Centre Hospitalier Universitaire UCL Namur Universit\u00e9 Catholique de Louvain Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hille","family":"Suojalehto","sequence":"additional","affiliation":[{"name":"Occcupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Wiszniewska","sequence":"additional","affiliation":[{"name":"Department of Occupational Diseases and Environmental Health Nofer Institute of Occupational Medicine Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Munoz","sequence":"additional","affiliation":[{"name":"Servei Pneumologia Hospital Vall d'Hebron Universitat Autonoma de Barcelona and CIBER de Enfermedades Respiratorias (CIBERES) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-6837","authenticated-orcid":false,"given":"Joaquin","family":"Sastre","sequence":"additional","affiliation":[{"name":"Department of Allergy Fundacion Jimenez D\u0131az and CIBER de Enfermedades Respiratorias (CIBERES) Madrid 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