{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:08:24Z","timestamp":1790197704812,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IgE\u2010mediated egg allergy presents as one of the most common food allergies in children. Measurement of egg white specific IgE (sIgE) levels in serum or skin prick test has been shown to be a poor predictor of clinical allergy to raw egg white, and also to baked or cooked egg. Recent developments in component resolved diagnostic (<jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content>) technology have enabled us to improve the way in which we diagnose and predict peanut allergy by examining IgE specificity to individual peptides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate whether egg <jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content> could improve current methods to diagnose various egg allergy phenotypes as well as predict the development of tolerance to egg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the HealthNuts cohort of food challenge\u2010proven egg allergic and egg\u2010sensitized and egg\u2010tolerant, age\u2010matched 12\u2010month infants with longitudinal follow\u2010up at 2 and 4\u00a0years (n\u00a0=\u00a0451), we measured serum egg white, Gal d 1, 2, 3 and 5 sIgE using Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gal d 1 sensitization increased the risk of persistent egg allergy by 2.5\u2010fold. The production of sIgE to all four egg allergens (Gal d 1, 2, 3 or 5) increased the risk of having persistent raw egg allergy fourfold (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.19 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.25\u201014.07). We did not find any improvements of using Gal d 1, 2, 3 or 5 to diagnose current egg allergy compared to egg white <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensitization to multiple egg allergens Gal d 1, 2, 3 or 5 may be a prognostic marker that could be useful for patient management and identifying individuals at risk of developing persistent egg allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13572","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T13:15:48Z","timestamp":1532351748000},"page":"318-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts"],"prefix":"10.1111","volume":"74","author":[{"given":"Thanh D.","family":"Dang","sequence":"first","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Peters","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Koplin","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"The Centre for Molecular, Environmental, Genetic and Analytic Epidemiology University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle C.","family":"Gurrin","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"The Centre for Molecular, Environmental, Genetic and Analytic Epidemiology University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Louise","family":"Ponsonby","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Martino","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Neeland","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"},{"name":"Department of Allergy and Immunology Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-4493","authenticated-orcid":false,"given":"Katrina\u00a0J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"},{"name":"Department of Allergy and Immunology Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HealthNuts study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00928.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.038"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00940.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.056"},{"key":"e_1_2_9_10_1","first-page":"S1","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID\u2010Sponsored Expert Panel","volume":"126","author":"NIAID\u2010Sponsored EP","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12153"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.04.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03915.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03562.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.11.018"},{"key":"e_1_2_9_19_1","unstructured":"ASCIA.Is it allergy? 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