{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:09Z","timestamp":1792043109566,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772271"],"award-info":[{"award-number":["31772271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Artemisia<\/jats:italic>\n                      pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to\n                      <jats:italic>Artemisia<\/jats:italic>\n                      allergen components and clinical phenotypes have not yet been evaluated. This study was to establish sensitization patterns of four\n                      <jats:italic>Artemisia<\/jats:italic>\n                      allergens and possible associations with demographic characteristics and clinical phenotypes in three areas of China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred and forty patients allergic to\n                      <jats:italic>Artemisia<\/jats:italic>\n                      pollen were examined, 178 from Shanxi and 30 from Shandong Provinces in Northern China, and 32 from Yunnan Province in Southwestern China. Allergic asthma, rhinitis, conjunctivitis, and eczema symptoms were diagnosed. All patients\u2019 sera were tested by Immuno\n                      <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\n                      with mugwort pollen extract and the natural components\n                      <jats:styled-content style=\"fixed-case\">nA<\/jats:styled-content>\n                      rt v 1,\n                      <jats:styled-content style=\"fixed-case\">nA<\/jats:styled-content>\n                      rt ar 2,\n                      <jats:styled-content style=\"fixed-case\">nA<\/jats:styled-content>\n                      rt v 3, and\n                      <jats:styled-content style=\"fixed-case\">nA<\/jats:styled-content>\n                      rt an 7.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The frequency of sensitization and the IgE levels of the four components in\n                      <jats:italic>Artemisia<\/jats:italic>\n                      allergic patients from Southwestern China were significantly lower than in those from the North. Art v 1 and Art an 7 were the most frequently recognized allergens (84% and 87%, respectively), followed by Art v 3 (66%) and Art ar 2 (48%). Patients from Northern China were more likely to have allergic asthma (50%) than patients from Southwestern China (3%), and being sensitized to more than two allergens increased the risk of allergic asthma, in which co\u2010sensitization to three major allergens Art v 1, Art v 3, and Art an 7 is prominent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Component\u2010resolved diagnosis of Chinese\n                      <jats:italic>Artemisia<\/jats:italic>\n                      pollen\u2010allergic patients helps assess the potential risk of mugwort\u2010associated allergic asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13597","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T02:41:52Z","timestamp":1535596912000},"page":"284-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["<i>Artemisia<\/i>\n                    pollen allergy in China: Component\u2010resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-9955","authenticated-orcid":false,"given":"Zhongshan","family":"Gao","sequence":"first","affiliation":[{"name":"Allergy Research Center Zhejiang University Hangzhou China"},{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou China"},{"name":"Department of Experimental Immunology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Yi","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Allergy Yu Huang Ding Hospital Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Hangzhou Aileji Biotech Ltd Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Allergy The Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Allergy The Third People's Hospital of Datong Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Mei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Qujing Chinese Traditional Medicine Hospital Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandong","family":"Wu","sequence":"additional","affiliation":[{"name":"Allergy Research Center Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Allergy Research Center Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Allergy The Third People's Hospital of Datong Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Allergy The Third People's Hospital of Datong Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2010Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Allergy Yu Huang Ding Hospital Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Qujing Chinese Traditional Medicine Hospital Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Shanxi Medical University Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-417X","authenticated-orcid":false,"given":"Gabriele","family":"Gadermaier","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Salzburg Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-2335","authenticated-orcid":false,"given":"Fatima","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Salzburg Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge A.","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"van Ree","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-31609-8_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.2.92"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01967.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-95"},{"key":"e_1_2_10_6_1","first-page":"18","article-title":"Two hundred thousands results of allergen specific IgE detection","volume":"6","author":"Wang RQ","year":"2012","journal-title":"Chin J Allergy Clin Immunol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-31609-8_4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/179426"},{"key":"e_1_2_10_9_1","unstructured":"YaoLN.Pollen survey by volumetric sampler in Beijing city and cross\u2010reactivity research between ragweed and mugwort in\u00a0vitro. PhD thesis Peking Union Medical College 2009; (in Chinese English abstract)."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12419"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12635"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438724"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13328"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1200185"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353113"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.042"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12563"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.06.014"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13375"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01780.x"},{"key":"e_1_2_10_24_1","unstructured":"DengS.Precision diagnosis of mugwort pollen\u2010associated food allergy in China PhD thesis Peking Union Medical College 2016."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320231"},{"key":"e_1_2_10_26_1","volume-title":"A National Survey of Airborne and Allergenic Pollen in China","author":"Ye ST","year":"1991"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500798"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13298"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02053.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.04.022"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446156"},{"key":"e_1_2_10_32_1","first-page":"626","article-title":"A report of 50 patients with artemisia pollenosis and plant food allergy","volume":"82","author":"Wen Z","year":"2002","journal-title":"Natl Med J China"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410407200"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120038"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13388"},{"key":"e_1_2_10_36_1","first-page":"97","article-title":"Comparison of the result from two airborne pollen surveys conducted in Taiyuan city during the past thirty years","volume":"5","author":"Zhang KJ","year":"2011","journal-title":"Chin J Allergy Clin Immunol"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:14:10Z","timestamp":1694682850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/all.13597"],"URL":"https:\/\/doi.org\/10.1111\/all.13597","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"assertion":[{"value":"2018-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}