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Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1\/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence\u2010based recommendations for the diagnosis and management of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    , a panel of international experts was called by the\n                    <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\n                    Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    . Recommendations for the most effective management of a patient with N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub\u2010phenotypes and emerging sub\u2010endotypes of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>\n                    and unmet needs, which should be addressed in the future.\n                  <\/jats:p>","DOI":"10.1111\/all.13599","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T03:57:30Z","timestamp":1537070250000},"page":"28-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":336,"title":["Diagnosis and management of\n                    <scp>NSAID<\/scp>\n                    \u2010Exacerbated Respiratory Disease (N\u2010\n                    <scp>ERD<\/scp>\n                    )\u2014a\n                    <scp>EAACI<\/scp>\n                    position paper"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-2774","authenticated-orcid":false,"given":"Marek 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